NLR immune receptors: structure and function in plant disease resistance.

Alexander Förderer, Jiorgos Kourelis

Journal: Biochemical Society transactions 2023;51(4):1473-1483

PMID: 37602488

Abstract

Nucleotide-binding and leucine-rich repeat receptors (NLRs) are a diverse family of intracellular immune receptors that play crucial roles in recognizing and responding to pathogen invasion in plants. This review discusses the overall model of NLR activation and provides an in-depth analysis of the different NLR domains, including N-terminal executioner domains, the nucleotide-binding oligomerization domain (NOD) module, and the leucine-rich repeat (LRR) domain. Understanding the structure-function relationship of these domains is essential for developing effective strategies to improve plant disease resistance and agricultural productivity.

© 2023 The Author(s).

Address: Max-Planck-Institute of Molecular Plant Physiology, 14476 Potsdam, Germany.; The Sainsbury Laboratory, University of East Anglia, Norwich Research Park, NR4 7UH Norwich, U.K.
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