Diabetes-associated neutrophil NETosis: pathogenesis and interventional target of diabetic complications.

Yuyan Zhu, Xuan Xia, Qian He, Qing-Ao Xiao, Decheng Wang, Meirong Huang, Xiaolin Zhang

Journal: Frontiers in endocrinology 2023;14():1202463

PMID: 37600700

Abstract

Neutrophil extracellular traps (NETs) are known as extracellular fibers networks consisting of antimicrobial proteins and decondensated chromatin DNA released by activated neutrophils. NETosis is a NETs-induced neutrophilic cell death which is unique from necrosis or apoptosis. Besides its neutralizing pathogen, NETosis plays a crucial role in diabetes and diabetes-related complications. In patients with diabetes, NETs-releasing products are significantly elevated in blood, and these findings confirm the association of NETosis and diabetic complications, including diabetic wound healing, diabetic retinopathy, and atherosclerosis. This article briefly summarizes the mechanisms of NETosis and discusses its contribution to the pathogenesis of diabetes-related complications and suggests new therapeutic targets by some small molecule compounds.

Copyright © 2023 Zhu, Xia, He, Xiao, Wang, Huang and Zhang.

Address: College of Basic Medical Science, China Three Gorges University, Yichang, China.; Institute of Infection and Inflammation, China Three Gorges University, Yichang, China.; Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges University, Yichang, China.; Department of Physiology and Pathophysiology, College of Basic Medical Science, China Three Gorges University, Yichang, China.; National Clinical Research Center for Metabolic Diseases, Hunan Provincial Key Laboratory of Metabolic Bone Diseases, Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.; Department of Interventional Radiology, The First College of Clinical Medical Science, China Three Gorges University, Yichang, Hubei, China.; Department of Interventional Radiology, Yichang Central People's Hospital, Yichang, Hubei, China.
Bant logo

© Copyright 2026, Nutrition Evidence

NED wishes to thank the following organisations for their support:

We use cookies to improve your experience and analyze site traffic with Google Analytics. By continuing to use our site, you agree to our use of cookies. Learn more.