Effects and mechanisms of tanshinone IIA on PTSD-like symptoms.

Kai-Bin Hu, Xiu-Min Lu, Hai-Yan Wang, Hui-Lin Liu, Qing-Yun Wu, Ping Liao, Sen Li, Zai-Yun Long, Yong-Tang Wang

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 2023;120():155032

PMID: 37611463

Full Text on Elsevier Science View on PubMed

Abstract

BACKGROUND

In recent years, Salvia miltiorrhiza and its active substances have remarkably progressed in treating central neurological disorders. Tanshinone IIA (TSA) is an active ingredient derived from the rhizome of Salvia miltiorrhiza that has been found to alleviate the symptoms of several psychiatric illnesses. Post-traumatic stress disorder (PTSD) is a mental disorder that results after experiencing a serious physical or psychological injury. The currently used drugs are not satisfactory for the treatment of PTSD. However, it has been reported that TSA can improve PTSD-like symptoms like learning and memory, cognitive disorder, and depression through multi-target regulation.

PURPOSE

This paper discusses the ameliorative effects of TSA on PTSD-like symptoms and the possible mechanisms of action in terms of inhibition of neuronal apoptosis, anti-neuroinflammation, and anti-oxidative stress. Based on the pathological changes and clinical observations of PTSD, we hope to provide some reference for the clinical transformation of Chinese medicine in treating PTSD.

METHODS

A large number of literatures on tanshinone in the treatment of neurological diseases and PTSD were retrieved from online electronic PubMed and Web of Science databases.

CONCLUSION

TSA is a widely studied natural active ingredient against mental illness. This review will contribute to the future development of TSA as a new clinical candidate drug for improving PTSD-like symptoms.

Address: State Key Laboratory of Trauma, Burns and Combined Injury, Daping Hospital, Army Medical University, Chongqing 400042, China; College of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing 400054, China.; College of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing 400054, China.; State Key Laboratory of Trauma, Burns and Combined Injury, Daping Hospital, Army Medical University, Chongqing 400042, China.; State Key Laboratory of Trauma, Burns and Combined Injury, Daping Hospital, Army Medical University, Chongqing 400042, China. Electronic address: [email protected].

DOI: 10.1016/j.phymed.2023.155032

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MeSH Terms: Humans, Stress Disorders, Post-Traumatic, Abietanes, Apoptosis, Oxidative Stress, Salvia miltiorrhiza