TMEM16A ion channel: A novel target for cancer treatment.

Shuting Li, Zhichen Wang, Ruili Geng, Weiwei Zhang, Haifu Wan, Xianjiang Kang, Shuai Guo

Journal: Life sciences 2023;331():122034

PMID: 37611692

Full Text on Elsevier Science View on PubMed

Abstract

Cancer draws attention owing to the high morbidity and mortality. It is urgent to develop safe and effective cancer therapeutics. The calcium-activated chloride channel TMEM16A is widely distributed in various tissues and regulates physiological functions. TMEM16A is abnormally expressed in several cancers and associate with tumorigenesis, metastasis, and prognosis. Knockdown or inhibition of TMEM16A in cancer cells significantly inhibits cancer development. Therefore, TMEM16A is considered as a biomarker and therapeutic target for some cancers. This work reviews the cancers associated with TMEM16A. Then, the molecular mechanism of TMEM16A overexpression in cancer was analyzed, and the possible signal transduction mechanism of TMEM16A regulating cancer development was summarized. Finally, TMEM16A inhibitors with anticancer effect and their anticancer mechanism were concluded. We hope to provide new ideas for pharmacological studies on TMEM16A in cancer.

Address: School of Life Sciences, Hebei University, Baoding 071002, Hebei, China.; School of Basic Medical Sciences, Hebei University, Baoding 071002, Hebei, China.; School of Life Sciences, Hebei University, Baoding 071002, Hebei, China; Institute of Life Sciences and Green Development, Hebei University, Baoding 071002, Hebei, China.; School of Life Sciences, Hebei University, Baoding 071002, Hebei, China; Institute of Life Sciences and Green Development, Hebei University, Baoding 071002, Hebei, China. Electronic address: [email protected].; School of Life Sciences, Hebei University, Baoding 071002, Hebei, China; Institute of Life Sciences and Green Development, Hebei University, Baoding 071002, Hebei, China. Electronic address: [email protected].

DOI: 10.1016/j.lfs.2023.122034

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MeSH Terms: Humans, Ion Channels, Neoplasms, Signal Transduction, Chloride Channels, Carcinogenesis, Calcium