MicroRNA and gynecological cancers: Focus on miR-195.

Mohammad Ali Mansournia, Zatollah Asemi, Nesa Rajabpoor Nikoo, Amirhossein Davoodvandi, Mahdi Rafiyan, Maryam Saati, Mansooreh Samimi

Journal: Pathology, research and practice 2023;249():154784

PMID: 37639954

Full Text on Elsevier Science View on PubMed

Abstract

Different cancer types have been shown to have down-regulated expression levels of miR-195 as an anti-tumor agent. MiR-195 family members can inhibit cancer cell proliferation, angiogenesis, epithelial-mesenchymal transition and metastases, immunosuppression, glycolysis, drug resistance, and cancer stem cell development by targeting the 3'-UTR of the mRNA of different pro-tumor genes. MiR-195 identified as a tumor suppressor miR in a variety of cancers, most notably gynecological malignancies such as cervical, endometrial, and ovarian carcinoma. As a result, restoring miR-195 expression should be regarded as a potential therapy for either prevention or treatment of gynecological cancers. This review will present the most recent data about miR-195-mediated anti-tumor effects in gynecological malignancies, emphasizing its downstream signaling pathways and target genes, as well as prospective treatment techniques.

Address: Cancer Immunology Project (CIP), Universal Scientific Education and Research Network (USERN), Tehran, Islamic Republic of Iran; Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Islamic Republic of Iran.; Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Islamic Republic of Iran. Electronic address: [email protected].; Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran.; Department of Gynecology and Obstetrics, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran. Electronic address: [email protected].; Department of Nursing, Semnan Branch, Islamic Azad University, Semnan, Islamic Republic of Iran.; Department of Gynecology and Obstetrics, Kashan University of Medical Sciences, Kashan, Islamic Republic of Iran. Electronic address: [email protected].; Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Islamic Republic of Iran. Electronic address: [email protected].

DOI: 10.1016/j.prp.2023.154784

Link outs

Free resources

Medical:

https://medlineplus.gov/ovariancancer.html

Research Materials:

https://antibodies.cancer.gov/detail/CPTC-HLA-B-1

Subscription / membership required

Full Text Sources:

https://linkinghub.elsevier.com/retrieve/pii/S0344...

MeSH Terms: Humans, Female, MicroRNAs, Genital Neoplasms, Female, Ovarian Neoplasms, Carcinoma, 3' Untranslated Regions