Substrate analogues to study cell-wall biosynthesis and its inhibition.

Kristi Lazar, Suzanne Walker

Journal: Current opinion in chemical biology 2003;6(6):786-93

PMID: 12470732

Full Text on Elsevier Science View on PubMed

Abstract

It has been known for more than 30 years that Lipid II is an intermediate in peptidoglycan synthesis. Recently, it has become apparent that it is also an important target of numerous antibiotics, including the glycopeptides, the lantibiotics and ramoplanin. It is also utilized by sortases in the construction of Gram-positive cell walls. Recent progress has been made in the synthesis of peptidoglycan intermediates that can be used to study enzymes which make peptidoglycan. These intermediates also enable studies to probe the mechanism of action of a variety of substrate-binding antibiotics.

Address: Department of Chemistry, Princeton University, Princeton, New Jersey 08544, USA. [email protected]

DOI: 10.1016/s1367-5931(02)00355-1

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MeSH Terms: Amino Acid Sequence, Anti-Bacterial Agents, Cell Wall, Glycosyltransferases, Gram-Negative Bacteria, Gram-Positive Bacteria, Lipid Metabolism, Lipids, Models, Biological, Molecular Sequence Data, Monosaccharides, Oligopeptides, Peptidoglycan, Protein Binding, Substrate Specificity, Uridine Diphosphate N-Acetylmuramic Acid