Mimicry of bioactive peptides via non-natural, sequence-specific peptidomimetic oligomers.

James A Patch, Annelise E Barron

Journal: Current opinion in chemical biology 2003;6(6):872-7

PMID: 12470744

Full Text on Elsevier Science View on PubMed

Abstract

Non-natural, sequence-specific peptidomimetic oligomers are being designed to mimic bioactive peptides, with potential therapeutic application. Cationic, facially amphipathic helical beta-peptide oligomers have been developed as magainin mimetics. Non-natural mimics of HIV-Tat protein, lung surfactant proteins, collagen, and somatostatin are also being developed. Pseudo-tertiary structure in beta-peptides and peptoids may herald the creation of entirely artificial proteins.

Address: Department of Chemical Engineering, Northwestern University, Evanston, Illinois 60208, USA.

DOI: 10.1016/s1367-5931(02)00385-x

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MeSH Terms: Amino Acid Sequence, Anti-Bacterial Agents, Anti-HIV Agents, Antimicrobial Cationic Peptides, Biomimetic Materials, Drug Design, Gene Products, tat, Humans, Molecular Sequence Data, Oligopeptides, Protein Structure, Secondary, Protein Structure, Tertiary