Biological properties of (1-4)-thio disaccharides.

Anna Czubatka-Bieńkowska, Joanna Sarnik, Tomasz Poplawski

Journal: Carbohydrate research 2023;533():108934

PMID: 37708795

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Abstract

Thio sugars are carbohydrate derivatives in which one or more oxygen atoms have been replaced with sulfur. Thio sugars are effective inhibitors of glycosylases, have considerable therapeutic potential, and are used as drugs in the treatment of diabetes and infectious diseases. The development of this branch of carbohydrate chemistry would not be possible without the development of novel methods for its synthesis and the analysis of their biochemical properties. In this Review Article, we summarize our findings on the biological properties of a collection of thio sugars and their derivatives synthesized by the Witczak and Bielski team using their original methods based on the Michael addition of sugar thiols to levoglucosenone.

Address: Department of Pharmaceutical Microbiology and Biochemistry, Medical University, 90-136, Lodz, Poland.; Department of Rheumatology, Medical University, 90-050, Lodz, Poland.; Department of Pharmaceutical Microbiology and Biochemistry, Medical University, 90-136, Lodz, Poland. Electronic address: [email protected].

DOI: 10.1016/j.carres.2023.108934

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MeSH Terms: Disaccharides, Thiosugars