Cardiovascular Molecular Imaging With Fluorine-19 MRI: The Road to the Clinic.

Ruud B van Heeswijk, Wolfgang R Bauer, Florian Bönner, Jelena M Janjic, Willem J M Mulder, Laura M Schreiber, Juerg Schwitter, Ulrich Flögel

Journal: Circulation. Cardiovascular imaging 2023;16(9):e014742

PMID: 37725674

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Abstract

Fluorine-19 (F) magnetic resonance imaging is a unique quantitative molecular imaging modality that makes use of an injectable fluorine-containing tracer that generates the only visible F signal in the body. This hot spot imaging technique has recently been used to characterize a wide array of cardiovascular diseases and seen a broad range of technical improvements. Concurrently, its potential to be translated to the clinical setting is being explored. This review provides an overview of this emerging field and demonstrates its diagnostic potential, which shows promise for clinical translation. We will describe F magnetic resonance imaging hardware, pulse sequences, and tracers, followed by an overview of cardiovascular applications. Finally, the challenges on the road to clinical translation are discussed.

Address: Department of Radiology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Switzerland (R.B.v.H.).; Department of Internal Medicine I, Universitätsklinikum Würzburg, Germany (W.R.B.).; Department of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty of Heinrich Heine University, University Hospital Düsseldorf, Germany (F.B.).; Graduate School of Pharmaceutical Sciences, School of Pharmacy, Duquesne University, Pittsburgh, PA (J.M.J.).; Laboratory of Chemical Biology, Department of Biochemical Engineering, Eindhoven University of Technology, the Netherlands (W.J.M.M.).; Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands (W.J.M.M.).; Chair of Molecular and Cellular Imaging, Comprehensive Heart Failure Center (CHFC), Wuerzburg University Hospitals, Germany (L.M.S.).; Division of Cardiology, Cardiovascular Department (J.S.), Lausanne University Hospital (CHUV), Switzerland.; CMR Center (J.S.), Lausanne University Hospital (CHUV), Switzerland.; Faculty of Biology and Medicine, University of Lausanne (UNIL), Switzerland (J.S.).; Experimental Cardiovascular Imaging (U.F.), Heinrich Heine University, Germany.; Cardiovascular Research Institute Düsseldorf (CARID) (U.F.), Heinrich Heine University, Germany.

DOI: 10.1161/CIRCIMAGING.123.014742

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MeSH Terms: Humans, Fluorine, Cardiovascular System, Cardiovascular Diseases, Molecular Imaging