Trauma and female reproductive health across the lifecourse: motivating a research agenda for the future of women's health.

Alexandra Hillcoat, Jaya Prakash, Leah Martin, Yu Zhang, Gabriela Rosa, Henning Tiemeier, Nicole Torres, Vicente Mustieles, Charleen D Adams, Carmen Messerlian

Journal: Human reproduction (Oxford, England) 2023;38(8):1429-1444

PMID: 37172265

Abstract

The aetiology behind many female reproductive disorders is poorly studied and incompletely understood despite the prevalence of such conditions and substantial burden they impose on women's lives. In light of evidence demonstrating a higher incidence of trauma exposure in women with many such disorders, we present a set of interlinked working hypotheses proposing relationships between traumatic events and reproductive and mental health that can define a research agenda to better understand reproductive outcomes from a trauma-informed perspective across the lifecourse. Additionally, we note the potential for racism to act as a traumatic experience, highlight the importance of considering the interaction between mental and reproductive health concerns, and propose several neuroendocrinological mechanisms by which traumatic experiences might increase the risk of adverse health outcomes in these domains. Finally, we emphasize the need for future primary research investigating the proposed pathways between traumatic experiences and adverse female reproductive outcomes.

© The Author(s) 2023. Published by Oxford University Press on behalf of European Society of Human Reproduction and Embryology. All rights reserved. For permissions, please email: [email protected].

Address: Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Department of Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Office of Educational Programs, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Department of Obstetrics and Gynecology, Vincent Center for Reproductive Biology, Massachusetts General Hospital Fertility Center, Boston, MA, USA.; Department of Radiology and Physical Medicine, School of Medicine, Center for Biomedical Research (CIBM), University of Granada, Granada, Spain.; Instituto de Investigación Biosanitaria Ibs GRANADA, Granada, Spain.; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain.
Bant logo

© Copyright 2026, Nutrition Evidence

NED wishes to thank the following organisations for their support:

We use cookies to improve your experience and analyze site traffic with Google Analytics. By continuing to use our site, you agree to our use of cookies. Learn more.