The differences in biological behavior and gene expression characteristics between pure and mixed early gastric signet ring cell carcinomas.

Xiaoyong Wang, Xuan Li, Peng Yang, Xiangrong Qin, Jing Yu, Yuqing Cheng, Guoxin Zhang, Liming Tang

Journal: Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2023;55(6):815-822

PMID: 36529637

Full Text on Elsevier Science View on PubMed

Abstract

BACKGROUND

The biological behavior of signet ring cell carcinoma (SRCC) in early gastric cancer (EGC) is not well understood.

AIMS

We aimed to investigate the clinicopathologic and prognostic differences, and explore differences in the gene expression characteristics between pure early SRCC and mixed early SRCC.

METHODS

We retrospectively analyzed 1707 EGC patients. We also conducted a meta-analysis to compare biological behavior in pure SRCC and mixed SRCC. We explored gene expression levels of N6-methyadenosine (m6A) regulators in pure SRCC and mixed SRCC.

RESULTS

Compared with pure SRCC, mixed SRCC was associated with an increased risk of submucosal invasion, perineural invasion, LVI and LNM. LNM was more common in mixed SRCC than with pure SRCC who met the indications for endoscopic submucosal dissection (ESD) (16.67% vs 2.78%). There was no difference in the overall survival between pure SRCC and mixed SRCC in EGCs (P=0.10). Expression of m6A regulators WTAP, FTO and VIRMA was significantly higher in mixed SRCC than that in pure SRCC (P<0.05).

CONCLUSION

Mixed SRCC displayed more aggressive biological behavior than pure SRCC in EGC. WTAP, FTO and VIRMA were expressed at significantly different levels in the two types of EGC, and may have important roles in the observed differences in biological behavior.

Address: Department of Gastroenterology, The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, 29 Xinglong Lane, Tianning District, Changzhou 213000, China.; Department of Gastroenterology, Jiangsu Province Hospital and Nanjing Medical University First Affiliated Hospital, Nanjing 210000, China.; Department of Pathology, The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, Changzhou 213000, China.; Department of General surgery, The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, Changzhou 213000, China. Electronic address: [email protected].

DOI: 10.1016/j.dld.2022.11.018

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MeSH Terms: Humans, Stomach Neoplasms, Retrospective Studies, Carcinoma, Signet Ring Cell, Prognosis, Gene Expression, Alpha-Ketoglutarate-Dependent Dioxygenase FTO