Elucidating the Risk of Colorectal Cancer for Variants in Hereditary Colorectal Cancer Genes.

Address: Colorectal Oncogenomics Group, Department of Clinical Pathology, The University of Melbourne, Parkville, Victoria, Australia; University of Melbourne Center for Cancer Research, Victorian Comprehensive Cancer Center, Parkville, Victoria, Australia; Melbourne Bioinformatics, The University of Melbourne, Parkville, Victoria, Australia.; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington.; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington; Department of Biostatistics, University of Washington, Seattle, Washington. Electronic address: [email protected].; Colorectal Oncogenomics Group, Department of Clinical Pathology, The University of Melbourne, Parkville, Victoria, Australia; University of Melbourne Center for Cancer Research, Victorian Comprehensive Cancer Center, Parkville, Victoria, Australia; Genomic Medicine and Family Cancer Clinic, The Royal Melbourne Hospital, Parkville, Victoria, Australia. Electronic address: [email protected].; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington; Department of Epidemiology, University of Washington, Seattle, Washington. Electronic address: [email protected].; Colorectal Oncogenomics Group, Department of Clinical Pathology, The University of Melbourne, Parkville, Victoria, Australia; University of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre, Parkville, Victoria, Australia.; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany.; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.; Service de Génétique Médicale, Centre Hospitalier Universitaire Nantes, Nantes, France.; Leeds Institute of Medical Research at St. James's, University of Leeds, Leeds, United Kingdom.; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany; Division of Preventive Oncology, German Cancer Research Center and National Center for Tumor Diseases, Heidelberg, Germany; German Cancer Consortium, German Cancer Research Center, Heidelberg, Germany.; Institute of Cancer Research, Department of Medicine I, Medical University Vienna, Vienna, Austria.; Institute for Health Research, Kaiser Permanente Colorado, Denver, Colorado.; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York.; Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia.; Gastroenterology Department, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, University of Barcelona, Barcelona, Spain.; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts.; Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany; University Medical Centre Hamburg-Eppendorf, University Cancer Centre Hamburg, Hamburg, Germany.; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany; Medical Faculty Heidelberg, Heidelberg University, Heidelberg, Germany.; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California.; Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy; Unit of Medical Oncology 2, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy.; Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania.; Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA.; Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.; Fundación Gallega de Medicina Genómica, Grupo de Genética del Cáncer, Instituto de Investigación Sanitaria de Santiago IDIS, Complejo Hospitalario Univ. Santiago-CHUS, SERGAS, Spain; University of California San Diego, Moores Cancer Center, La Jolla, CA.; Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.; Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia.; Nutrition and Metabolism Branch, International Agency for Research on Cancer, World Health Organization, Lyon, France.; Department of Medicine I, University Hospital Dresden, Technische Universität Dresden, Dresden, Germany.; Division of Human Genetics, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio.; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington; Department of Epidemiology, University of Washington, Seattle, Washington.; Center for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill, North Carolina.; Department of Genetics, Stanford University, Stanford, California; Department of Computer Science, Stanford University, Stanford, California.; University of Hawaii Cancer Center, Honolulu, Hawaii.; Department of Medicine, University of Southern California, Los Angeles, California.; Department of Family Medicine, University of Virginia, Charlottesville, Virginia.; Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.; Oncology Data Analytics Program, Catalan Institute of Oncology-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain; CIBER Epidemiología y Salud Pública, Madrid, Spain; Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona, Spain; ONCOBEL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain.; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington; School of Public Health, University of Washington, Seattle, Washington.; Department of Population Science, American Cancer Society, Atlanta, Georgia.; Oncology Data Analytics Program, Catalan Institute of Oncology-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain; CIBER Epidemiología y Salud Pública, Madrid, Spain.; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts; Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; Cancer Immunology Program, Dana-Farber/Harvard Cancer Center, Boston, Massachusetts.; Department of Laboratory Medicine and Pathology, Mayo Clinic Arizona, Scottsdale, Arizona.; Boston University School of Public Health, Boston, Massachusetts; Slone Epidemiology Center, Boston University, Boston, Massachusetts.; Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington; Research Centre for Hauora and Health, Massey University, Wellington, New Zealand.; Department of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel; Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel; Clalit National Cancer Control Center, Haifa, Israel.; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington; Division of Research, Kaiser Permanente Northern California, Oakland, California.; Department of General Surgery, University Hospital Rostock, Rostock, Germany.; Genomic Medicine Institute, Cleveland Clinic, Cleveland, Ohio; Population and Cancer Prevention Program, Case Comprehensive Cancer Center, Cleveland, Ohio.; Departments of Medicine and Epidemiology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.; Department of Internal Medicine, University of Utah, Salt Lake City, Utah.; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.; Division of Laboratory Genetics, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota.; Huntsman Cancer Institute and Department of Population Health Sciences, University of Utah, Salt Lake City, Utah.; Division of Human Nutrition and Health, Wageningen University & Research, Wageningen, the Netherlands.; Department of Radiation Sciences, Oncology Unit, Umeå University, Umeå, Sweden; Wallenberg Centre for Molecular Medicine, Umeå University, Umeå, Sweden.; Department of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech Republic; Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Prague, Czech Republic; Faculty of Medicine and Biomedical Center in Pilsen, Charles University, Pilsen, Czech Republic.; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington; Department of Epidemiology, University of Washington School of Public Health, Seattle, Washington.; Department of Medicine, The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia; Genomic Medicine and Family Cancer Clinic, The Royal Melbourne Hospital, Parkville, Victoria, Australia.; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.; Department of Medical Oncology and Therapeutics Research, City of Hope National Medical Center, Duarte, California.; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.