Prebiotics: Ignored player in the fight against cancer.

Parichita Mishra, Vidhi Manish Badiyani, Sakshi Jain, Sruti Subramanian, Sakshee Vinay Maharaj, Ashwini Kumar, Bhisham Narayan Singh

Journal: Cancer reports (Hoboken, N.J.) 2023;6(11):e1870

PMID: 37458148

Abstract

BACKGROUND

Prebiotics is a relatively neglected area in cancer research, despite evidence suggesting that it plays a key role in suppressing tumour growth and improving immune function.

RECENT FINDINGS

Including prebiotics in the diet has been shown to strengthen the immune system and can better slow down or prevent the growth of tumours. It has also been strongly indicated in various scientific studies that prebiotics can contribute to the sustenance of a healthy microbiome, which in turn plays an important role in increasing the effectiveness and reducing the side effects of cancer treatments.

CONCLUSION

In the present review article we highlight the mechanisms by which prebiotics like inulin, fructooligosaccharide (FOS), β-glucan, pectin, and xylooligosaccharide (XOS) function. Furthermore, the beneficial effect of incorporating prebiotics during cancer therapy to improvise gut health and prevent/reverse the damage caused to patients due to chemotherapy has also been elaborated.

© 2023 The Authors. Cancer Reports published by Wiley Periodicals LLC.

Address: Department of Ageing Research, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, India.; Biotechnology and Bioinformatics Area, NIIT University, Neemrana, Rajasthan, India.
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