The redox riddle of selenium sulfide.

Eduard Tiganescu, Ahmad Yaman Abdin, Afraa Razouk, Muhammad Jawad Nasim, Claus Jacob

Journal: Current opinion in chemical biology 2023;76():102365

PMID: 37463529

Full Text on Elsevier Science View on PubMed

Abstract

Selenium sulfide, in analogy with selenium dioxide, is often considered as SeS. At closer inspection, however, selenium sulfide represents a large family of rather complicated molecules which differ depending on the mode of preparation. Together, these compounds share extraordinarily low solubility in virtually any solvent with a biological activity rather impressive for such simple molecules. The surface reactivity of such microscopic and nanoscopic materials, prepared chemically or by fermentation, may provide an answer to this riddle and explain activities by a combination of physical, redox, metal binding, covalent, and non-covalent interactions with biomolecules and cells.

Address: Division of Bioorganic Chemistry, School of Pharmacy, Saarland University, D-66123 Saarbruecken, Germany.; Division of Bioorganic Chemistry, School of Pharmacy, Saarland University, D-66123 Saarbruecken, Germany. Electronic address: [email protected].; Division of Bioorganic Chemistry, School of Pharmacy, Saarland University, D-66123 Saarbruecken, Germany. Electronic address: [email protected].

DOI: 10.1016/j.cbpa.2023.102365

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MeSH Terms: Selenium, Oxidation-Reduction, Selenium Compounds, Fermentation