Association of rs9939609 in FTO with BMI among Polynesian peoples living in Aotearoa New Zealand and other Pacific nations.

Mohanraj Krishnan, Amanda Phipps-Green, Emily M Russell, Tanya J Major, Murray Cadzow, Lisa K Stamp, Nicola Dalbeth, Jennie Harré Hindmarsh, Muhammad Qasim, Huti Watson, Shuwei Liu, Jenna C Carlson, Ryan L Minster, Nicola L Hawley, Take Naseri, Muagututi'a Sefuiva Reupena, Ranjan Deka, Stephen T McGarvey, Tony R Merriman, Rinki Murphy, Daniel E Weeks

Journal: Journal of human genetics 2023;68(7):463-468

PMID: 36864286

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Abstract

The fat mass and obesity associated (FTO) locus consistently associates with higher body mass index (BMI) across diverse ancestral groups. However, previous small studies of people of Polynesian ancestries have failed to replicate the association. In this study, we used Bayesian meta-analysis to test rs9939609, the most replicated FTO variant, for association with BMI with a large sample (n = 6095) of Aotearoa New Zealanders of Polynesian (Māori and Pacific) ancestry and of Samoan people living in the Independent State of Samoa and in American Samoa. We did not observe statistically significant association within each separate Polynesian subgroup. Bayesian meta-analysis of the Aotearoa New Zealand Polynesian and Samoan samples resulted in a posterior mean effect size estimate of +0.21 kg/m, with a 95% credible interval [+0.03 kg/m, +0.39 kg/m]. While the Bayes Factor (BF) of 0.77 weakly favors the null, the BF = 1.4 Bayesian support interval is [+0.04, +0.20]. These results suggest that rs9939609 in FTO may have a similar effect on mean BMI in people of Polynesian ancestries as previously observed in other ancestral groups.

Address: Department of Human Genetics, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Biochemistry, University of Otago, Dunedin, New Zealand.; Department of Medicine, University of Otago, Christchurch, New Zealand.; Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.; Maurice Wilkins Centre, Auckland, New Zealand.; Ngāti Porou Hauora Charitable Trust, Te Puia Springs, Tairāwhiti East Coast, New Zealand.; Department of Human Genetics, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Biostatistics, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Chronic Disease Epidemiology, School of Public Health, Yale University, New Haven, CT, USA.; Ministry of Health, Government of Samoa, Apia, Samoa.; International Health Institute, Department of Epidemiology, School of Public Health, Brown University, Providence, RI, USA.; Lutia i Puava ae Mapu i Fagalele, Apia, Samoa.; Department of Environmental and Public Health Sciences, College of Medicine, University of Cincinnati, Cincinnati, OH, USA.; International Health Institute, Department of Epidemiology, School of Public Health, Brown University, Providence, RI, USA.; Department of Anthropology, Brown University, Providence, RI, USA.; Department of Human Genetics, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA. [email protected].; Department of Biostatistics, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA. [email protected].

DOI: 10.1038/s10038-023-01141-5

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MeSH Terms: Humans, Alpha-Ketoglutarate-Dependent Dioxygenase FTO, Bayes Theorem, Body Mass Index, Genetic Predisposition to Disease, Maori People, New Zealand, Pacific Island People, Polymorphism, Single Nucleotide