Morus alba: a comprehensive phytochemical and pharmacological review.

Gaber El-Saber Batiha, Ali Esmail Al-Snafi, Mahdi M Thuwaini, John Oluwafemi Teibo, Hazem M Shaheen, Ayomide Peter Akomolafe, Titilade Kehinde Ayandeyi Teibo, Hayder M Al-Kuraishy, Ali I Al-Garbeeb, Athanasios Alexiou, Marios Papadakis

Journal: Naunyn-Schmiedeberg's archives of pharmacology 2023;396(7):1399-1413

PMID: 36877269

Abstract

Morus alba is a fast-growing shrub or medium-sized tree with a straight, cylindrical trunk. Medicinally, whole plants, leaves, fruits, branches, and roots have been employed. Google Scholar, PubMed, Scopus, and Web of Science were used to search for relevant material on the phytochemical components and pharmacologic and mechanism of action of the Morus alba. This was reviewed to assess important updates about Morus alba. The fruits of Morus alba have traditionally been used as an analgesic, anthelmintic, antibacterial, anti-rheumatic, diuretic, hypotensive, hypoglycemia, purgative, restorative, sedative tonic, and blood stimulant. Various plant parts were used as a cooling, sedating, diuretic, tonic, and astringent agent to treat nerve disorders. The plant contained tannins, steroids, phytosterols, sitosterol, glycosides, alkaloids, carbohydrates, proteins, and amino acids, as well as saponins, triterpenes, phenolics, flavonoids, benzofuran derivatives, anthocyanins, anthraquinones, glycosides, vitamins, and minerals. Previous pharmacological research identified antimicrobial, anti-inflammatory, immunological, analgesic, antipyretic, antioxidant, anti-cancer, antidiabetic, gastrointestinal, respiratory, cardiovascular, hypolipidemic, anti-obesity, dermatological, neurological, muscular, and protecting effects. This study looked at Morus alba's traditional uses, chemical components, and pharmacological effects.

© 2023. The Author(s).

Address: Department of Pharmacology and Therapeutics, Faculty of Veterinary Medicine, Damanhour University, Damanhour, 22511, El Beheira, Egypt. [email protected].; Department of Pharmacology, College of Medicine, University of Thi-Qar, Nasiriyah, Iraq.; College of Medical and Healthy Techniques, Southern Technique University, Basra, Iraq.; Department of Biochemistry and Immunology, Ribeirão, Preto Medical School , University of São Paulo, Ribeirão Preto, São Paulo, Brazil. [email protected].; Department of Pharmacology and Therapeutics, Faculty of Veterinary Medicine, Damanhour University, Damanhour, 22511, El Beheira, Egypt.; Department of Biochemistry, University of Ibadan, Ibadan, Nigeria.; Department of Maternal-Infant and Public Health Nursing, College of Nursing, University of São Paulo, Ribeirão PretoRibeirão Preto, São Paulo, Brazil.; Department of Clinical Pharmacologyand, Therapeutic Medicine, College of Medicine , Almustansiriyah University, Baghdad, Iraq.; Department of Science and Engineering, Novel Global Community Educational Foundation, Hebersham, NSW, 2770, Australia.; AFNP Med, 1030, Vienna, Austria.; Department of Surgery II, University Hospital Witten-Herdecke, University of Witten-Herdecke, Heusnerstrasse 40, 42283, Wuppertal, Germany. [email protected].
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