Consensus document on acute-on-chronic liver failure (ACLF) established by the Mexican Association of Hepatology.

Judith Flores-Calderón, Francisco Alfonso Solís-Galindo, Linda Elsa Muñoz-Espinosa, Víctor Manuel Páez-Zayas, Belinda Isela Martínez-Saldívar, Godolfino Miranda-Zazueta, Nayeli Cointa Flores-García, Jacqueline Córdova-Gallardo, Ernesto Márquez-Guillén, Mario Vilatobá, Iaarah Montalvo-Gordon, René Malé-Velázquez, Nancy Allin Canedo-Castillo, Ignacio García-Juárez, Fatima Higuera-de-la-Tijera, Aldo Torre, Jonathan Aguirre-Valádez, Carlos Moctezuma-Velázquez, Luis Carlos Solís-Gasca, Norberto C Chavez-Tapia, Rafael Trejo-Estrada, Jesús Alejandro Ruiz-Manríquez, Osvely Méndez-Guerrero, José Luís Pérez-Hernández, María Sarai González-Huezo, Ricardo Sandoval-Salas, Nalu Navarro-Alvarez, Mauricio Castillo-Barradas, Laura Esthela Cisneros-Garza

Journal: Annals of hepatology 2024;28(6):101140

PMID: 37482299

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Abstract

Acute-on chronic liver failure (ACLF) has been an intensively debated topic mainly due to the lack of a unified definition and diagnostic criteria. The growing number of publications describing the mechanisms of ACLF development, the progression of the disease, outcomes and treatment has contributed to a better understanding of the disease, however, it has also sparked the debate about this condition. As an attempt to provide medical professionals with a more uniform definition that could be applied to our population, the first Mexican consensus was performed by a panel of experts in the area of hepatology in Mexico. We used the most relevant and impactful publications along with the clinical and research experience of the consensus participants. The consensus was led by 4 coordinators who provided the most relevant bibliography by doing an exhaustive search on the topic. The entire bibliography was made available to the members of the consensus for consultation at any time during the process and six working groups were formed to develop the following sections: 1.- Generalities, definitions, and criteria, 2.- Pathophysiology of cirrhosis, 3.- Genetics in ACLF, 4.- Clinical manifestations, 5.- Liver transplantation in ACLF, 6.- Other treatments.

Published by Elsevier España, S.L.U.

Address: Metabolic Unit, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico. Electronic address: [email protected].; Gastroenterology and Hepatology Department, Hospital Christus Muguerza Alta Especialidad, Monterrey, Nuevo León, Mexico.; Gastroenterology Department, Centro Médico Nacional La Raza, Mexico City, Mexico.; Gastroenterology Department, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.; Gastroenterology Department, Centro Médico Nacional Siglo XXI, Mexico City, Mexico.; Gastroenterology Department, Centro Médico Nacional La Raza, Toluca, Estado de México, Mexico.; Gastroenterology and Hepatology Department, Hospital General de México, Mexico City, Mexico.; Centro Médico ABC, Mexico City, Mexico.; Gastroenterology Department, Fundación Clínica Médica Sur, Mexico City, Mexico.; Gastroenterology Department, Hospital General de Zona #12 Benito Juárez del Instituto Mexicano del Seguro Social, Mérida, Yucatán, Mexico.; Gastroenterology Department, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico; Department of Medicine - Division of Gastroenterology (Liver Unit), University of Alberta, Edmonton, Alberta, Canada.; Hospital Ángeles del Pedregal, Mexico City, Mexico.; Pediatrics Department, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Mexico City, Mexico.; Intensive Care Unit, Centro Médico Nacional "La Raza", Mexico City, Mexico.; Centro de Enfermedades Digestivas y Hepáticas, Guadalajara, Jalisco, Mexico.; Clinic of Gastrointestinal and Hepatic Specialties, Hospital Faro del Mayab, Mérida, Yucatán, Mexico.; Transplant Department, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.; Gastroenterology Department, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico; Hospital Ángeles del Pedregal, Mexico City, Mexico.; Hepatology Department - General Surgery Service, Hospital General Dr. Manuel Gea González, Mexico City, Mexico.; Transplant Unit, Centro Médico Nacional La Raza, Mexico City, Mexico.; Transplant Unit, Hospital General de México, Mexico City, Mexico.; Universidad Autónoma de Nuevo León. Liver Unit, Department of Internal Medicine, University Hospital 'Dr. José E. González', Monterrey, Nuevo León, Mexico.; Gastroenterology Department, Unidad Médica de Alta Especialidad # 71 Instituto Mexicano del Seguro Social, Torreón, Coahuila, Mexico.

DOI: 10.1016/j.aohep.2023.101140

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https://linkinghub.elsevier.com/retrieve/pii/S1665...

Research Materials:

https://antibodies.cancer.gov/detail/CPTC-HLA-B-1

MeSH Terms: Humans, Acute-On-Chronic Liver Failure, Mexico, Consensus, Gastroenterology, Liver Transplantation, Liver Cirrhosis