Phytotherapy of abnormality of fear memory: A narrative review of mechanisms.

Shaojie Yang, Guoqi Zhu

Journal: Fitoterapia 2023;169():105618

PMID: 37482307

Full Text on Elsevier Science View on PubMed

Abstract

It is generally believed that in post-traumatic stress disorder (PTSD), the high expression of fear memory is mainly determined by amygdala hyperactivity and hippocampus hypoactivity. In this review, we firstly updated the mechanisms of fear memory, and then searched the experimental evidence of phytotherapy for fear memory in the past five years. Based on the summary of those experimental studies, we further discussed the future research strategies of plant medicines, including the study of the mechanism of specific brain regions, the optimal time for the prevention and treatment of fear memory-related diseases such as PTSD, and the development of new drugs with active components of plant medicines. Accordingly, plant medicines play a clear role in improving fear memory abnormalities and have the drug development potential in the treatment of fear-related disorders.

Address: The Second Affiliation Hospital of Anhui University of Chinese Medicine, Hefei, Anhui 230061, China; Key Laboratory of Xin'an Medicine, The Ministry of Education and Key Laboratory of Molecular Biology (Brain diseases), Anhui University of Chinese Medicine, Hefei, Anhui 230012, China.; Key Laboratory of Xin'an Medicine, The Ministry of Education and Key Laboratory of Molecular Biology (Brain diseases), Anhui University of Chinese Medicine, Hefei, Anhui 230012, China. Electronic address: [email protected].

DOI: 10.1016/j.fitote.2023.105618

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https://linkinghub.elsevier.com/retrieve/pii/S0367...

MeSH Terms: Memory, Molecular Structure, Fear, Amygdala, Phytotherapy