Insights into the role of N6-methyladenosine in ferroptosis.

N6-methyladenosine (mA) methylation modification is one of the most prevalent epigenetic modifications of eukaryotic RNA. mA methylation is widely associated with many biological processes through the modification of RNA metabolism and is associated with multiple disease states. As a newly discovered regulatory cell death in recent years, ferroptosis is an iron-dependent cell death characterized by excessive lipid peroxidation. Emerging evidence supports that ferroptosis has a significant role in the progression of diverse diseases. Besides, the key regulators of ferroptosis exhibit aberrant mA levels under different pathological conditions. However, the correlation between mA-modified ferroptosis and multiple diseases has not been well elucidated. In this review, we summarized the functions of mA in ferroptosis, which are associated with the initiation and progression of multiple diseases. Investigating the role of mA in ferroptosis might both facilitate a better understanding of the pathogenesis of these diseases and provide new opportunities for targeted treatment.

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