Cardiac troponin I is increased after interventional closure of atrial septal defects.

Christiane Pees, Nikolaus A Haas, Joachim von der Beek, Peter Ewert, Felix Berger, Peter E Lange

Journal: Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 2003;58(1):124-9

PMID: 12508215

Full Text on Wiley View on PubMed

Abstract

This study was designed to assess possible myocardial injury caused by interventional closure of atrial septal defects (ASDs) compared to diagnostic catheterization by measuring cardiac troponin I (cTn-I). Forty patients were enrolled; in 33 ASDs were successfully closed, while in 7 a diagnostic balloon sizing of the defect was performed only. Total cTn-I increased significantly from 0.1 to 1.9 microg/l at the end of the intervention and 2.23 at 4 hr and decreased to 1.35 at 15 hr. No significant increase could be detected in patients with diagnostic balloon sizing only or of CK/CK-MB levels either. Following interventional closure of ASDs with Amplatzer septum/PFO occluders, increased cTn-I levels for several hours indicate some transient, reversible myocardial membrane instability due to the device. Discrimination of ventricular myocardial infarction might be possible by estimating less sensitive CK and CK-MB levels only.

Address: Department for Congenital Heart Defects and Pediatrics Cardiology, German Heart Center Berlin, Berlin, Germany. [email protected]

DOI: 10.1002/ccd.10398

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Full Text Sources:

https://doi.org/10.1002/ccd.10398

MeSH Terms: Adolescent, Adult, Aged, Balloon Occlusion, Cardiac Catheterization, Child, Creatine Kinase, Creatine Kinase, MB Form, Female, Heart Injuries, Heart Septal Defects, Atrial, Humans, Isoenzymes, Male, Middle Aged, Postoperative Complications, Time Factors, Troponin I