The apocarotenoid production in microbial biofactories: An overview.

Ressin Varghese, Tinamoni Buragohain, Ishani Banerjee, Rishyani Mukherjee, Shraddha Naresh Penshanwar, Swapna Agasti, Siva Ramamoorthy

Journal: Journal of biotechnology 2023;374():5-16

PMID: 37499877

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Abstract

Carotenoids are a vast group of natural pigments that come in a variety of colors ranging from red to orange. Apocarotenoids are derived from these carotenoids, which are hormones, pigments, retinoids, and volatiles employed in the textiles, cosmetics, pharmaceutical, and food industries. Due to the high commercial value and poor natural host abundance, they are significantly undersupplied. Microbes like Saccharomyces cerevisiae and Escherichia coli act as heterologous hosts for apocarotenoid production. This article briefly reviews categories of apocarotenoids, their biosynthetic pathway commencing from the MVA and MEP, its significance, the tool enzymes for apocarotenoid biosynthesis like CCDs, their biotechnological production in microbial factories, and future perspectives.

Address: School of Bio Sciences and Technology, Vellore Institute of Technology, Vellore 632014, Tamil Nadu, India.; School of Bio Sciences and Technology, Vellore Institute of Technology, Vellore 632014, Tamil Nadu, India. Electronic address: [email protected].

DOI: 10.1016/j.jbiotec.2023.07.009

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MeSH Terms: Dioxygenases, Carotenoids, Retinoids