SERRATE: a key factor in coordinated RNA processing in plants.

Monika Jozwiak, Dawid Bielewicz, Zofia Szweykowska-Kulinska, Artur Jarmolowski, Mateusz Bajczyk

Journal: Trends in plant science 2023;28(7):841-853

PMID: 37019716

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Abstract

The SERRATE (SE) protein is involved in the processing of RNA polymerase II (RNAPII) transcripts. It is associated with different complexes engaged in different aspects of plant RNA metabolism, including assemblies involved in transcription, splicing, polyadenylation, miRNA biogenesis, and RNA degradation. SE stability and interactome properties can be influenced by phosphorylation. SE exhibits an intriguing liquid-liquid phase separation property that may be important in the assembly of different RNA-processing bodies. Therefore, we propose that SE seems to participate in the coordination of different RNA-processing steps and can direct the fate of transcripts, targeting them for processing or degradation when they cannot be properly processed or are synthesized in excess.

Address: Department of Gene Expression, Institute of Molecular Biology and Biotechnology, Adam Mickiewicz University, Poznan, Poland.; Center for Advanced Technology, Adam Mickiewicz University, Poznan, Poland.; Department of Gene Expression, Institute of Molecular Biology and Biotechnology, Adam Mickiewicz University, Poznan, Poland. Electronic address: [email protected].; Department of Gene Expression, Institute of Molecular Biology and Biotechnology, Adam Mickiewicz University, Poznan, Poland. Electronic address: [email protected].

DOI: 10.1016/j.tplants.2023.03.009

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MeSH Terms: Arabidopsis Proteins, Arabidopsis, Calcium-Binding Proteins, RNA Processing, Post-Transcriptional, Serrate-Jagged Proteins, RNA, MicroRNAs, RNA, Plant, Gene Expression Regulation, Plant