C adduct with L-arginine as a promising nanomaterial for treating cerebral ischemic stroke.

Olegi N Kukaliia, Sergei V Ageev, Andrey V Petrov, Olga V Kirik, Dmitrii E Korzhevskii, Anatolii A Meshcheriakov, Anastasia A Jakovleva, Liudmila S Poliakova, Tatiana A Novikova, Maria E Kolpakova, Timur D Vlasov, Oleg E Molchanov, Dmitriy N Maistrenko, Igor V Murin, Vladimir V Sharoyko, Konstantin N Semenov

Journal: Nanomedicine : nanotechnology, biology, and medicine 2023;53():102698

PMID: 37507062

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Abstract

The work aimed to investigate the biocompatibility and biological activity of the water-soluble fullerene adduct C-Arg. It was found that the material is haemocompatible, is not cyto- and genotoxic, possesses pronounced antioxidant activity. Additionally, this paper outlines the direction of application of water-soluble fullerene adducts in the creation of neuroprotectors. It has been suggested that a putative mechanism of the protective action of the C-Arg adduct is associated with its antioxidant properties, the ability to penetrate the blood-brain barrier, and release nitrogen monoxide as a result of the catabolism of L-arginine residues, which promote vascular relaxation. The action of the C-Arg adduct was compared with the action of such an antioxidant as Edaravone, which is approved in Japan for the treatment of ischemic and haemorrhagic strokes.

Address: Pavlov First Saint Petersburg State Medical University, 6-8 L'va Tolstogo Str., Saint Petersburg, 197022, Russia.; Pavlov First Saint Petersburg State Medical University, 6-8 L'va Tolstogo Str., Saint Petersburg, 197022, Russia; Institute of Chemistry, Saint Petersburg State University, 26 Universitetskii Pr., Saint Petersburg, 198504, Russia.; Institute of Chemistry, Saint Petersburg State University, 26 Universitetskii Pr., Saint Petersburg, 198504, Russia.; Institute of Experimental Medicine, 12 Akademika Pavlova Str., Saint Petersburg, 197022, Russia.; A. M. Granov Russian Research Centre for Radiology and Surgical Technologies, 70 Leningradskaia Str., Saint Petersburg, 197758, Russia.; Pavlov First Saint Petersburg State Medical University, 6-8 L'va Tolstogo Str., Saint Petersburg, 197022, Russia; Institute of Chemistry, Saint Petersburg State University, 26 Universitetskii Pr., Saint Petersburg, 198504, Russia; A. M. Granov Russian Research Centre for Radiology and Surgical Technologies, 70 Leningradskaia Str., Saint Petersburg, 197758, Russia. Electronic address: [email protected].; Pavlov First Saint Petersburg State Medical University, 6-8 L'va Tolstogo Str., Saint Petersburg, 197022, Russia; Institute of Chemistry, Saint Petersburg State University, 26 Universitetskii Pr., Saint Petersburg, 198504, Russia; A. M. Granov Russian Research Centre for Radiology and Surgical Technologies, 70 Leningradskaia Str., Saint Petersburg, 197758, Russia. Electronic address: [email protected].

DOI: 10.1016/j.nano.2023.102698

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MeSH Terms: Humans, Antioxidants, Fullerenes, Ischemic Stroke, Nanostructures, Water, Stroke, Ischemia, Arginine