Low concentration of sodium tetradecyl sulfate and hypertonic glucose solution for the treatment of telangiectasia: A prospective randomized clinical trial.

Oksana V Bukina, Aleksandr A Sinitsyn, Oksana I Efremova, Andrey V Pelevin

Journal: Phlebology 2024;38(9):622-627

PMID: 37519033

Abstract

OBJECTIVES

This study aimed to compare telangiectasias disappearance after sclerotherapy with hypertonic glucose (HG) and different concentrations of sodium tetradecyl sulfate (STS).

METHODS

Women aged 18-70 years with telangiectasias were included. The primary efficacy endpoint was telangiectasia disappearance. The clearing of vessels was assessed using a six-point scale (from 0 to 5).

RESULTS

A total of 116 women completed an 8-week follow-up: 31, 27, 25, and 33 were in the HG 75%, STS 0.05%, STS 0.1%, and STS 0.15% groups, respectively. The median score of vein disappearance was significantly lower in the STS 0.05% (3, 0.25-4), STS 0.1% (3, 1.25-4), and STS 0.15% (4, 2-4) groups than in the HG group (4, 3-5) after 56 days, = .00002.

CONCLUSION

Sclerotherapy of telangiectasias with 75% HG showed significantly better results than low concentrations of STS.

TRIAL REGISTRATION

ClinicalTrials.gov NCT04132323.

Address: The Clinic (Doctor Profi), Derzhavin Tambov State University, Tambov, Russia.; The Clinic (Mir Zdorovja), Kursk, Russia.; Pirogov Russian National Research Medical University, Moscow, Russia.; Medical Diagnostic Center (Hippocrates), Ivanovo, Russia.

DOI: 10.1177/02683555231191969

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MeSH Terms: Humans, Female, Sodium Tetradecyl Sulfate, Sclerosing Solutions, Glucose Solution, Hypertonic, Prospective Studies, Telangiectasis, Sclerotherapy