Effect of passive smoking exposure on risk of type 2 diabetes: a systematic review and meta-analysis of prospective cohort studies.

Guo-Qiang Qin, Li Chen, Jun Zheng, Xiao-Min Wu, Yang Li, Kai Yang, Tong-Feng Liu, Zhong-Ze Fang, Qiang Zhang

Journal: Frontiers in endocrinology 2023;14():1195354

PMID: 37600719

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Abstract

OBJECTIVE

The effect of passive smoking exposure on the risk of type 2 diabetes has not been systematically studied. A meta-analysis was conducted to assess the association between passive smoking exposure and the risk of diabetes.

METHODS

We searched three major databases up to 31 October 2022 to identify relevant prospective cohort studies on the association between passive smoking and the risk of type 2 diabetes. The pooled relative risk (RR) and 95% confidence interval (CI) for the association between passive smoking exposure and the risk of type 2 diabetes were analyzed using a fixed-effect model.

RESULTS

Ten prospective cohort studies were included in this meta-analysis, with a total of 251,620 participants involved. The pooled RR showed a significantly positive association between nonsmokers exposed to passive smoking and type 2 diabetes as compared to non-smokers who were not exposed to passive smoking [RR = 1.27; 95% CI (1.19, 1.36); p < 0.001]. Sensitivity analysis indicated that the pooled RR was not substantially affected by any of the individual studies.

CONCLUSION

Exposure to passive smoking increases the risk of type 2 diabetes. This study may have a positive effect on the prevention of type 2 diabetes.

SYSTEMATIC REVIEW REGISTRATION

https://www.crd.york.ac.uk/PROSPERO/, identifier CRD42023372532.

Address: Department of Geriatrics, Tianjin Medical University General Hospital, Tianjin Key Laboratory of Elderly Health, Tianjin Geriatrics Institute, Tianjin, China.; Department of Toxicology and Sanitary Chemistry, School of Public Health, Tianjin Medical University, Tianjin, China.; Department of Epidemiology and Biostatistics, School of Public Health, Tianjin Medical University, Tianjin, China.; National Center for Chronic and Noncommunicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.; Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin, China.; National Demonstration Center for Experimental Preventive Medicine Education, Tianjin Medical University, Tianjin, China.

DOI: 10.3389/fendo.2023.1195354

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https://medlineplus.gov/diabetestype2.html

MeSH Terms: Humans, Diabetes Mellitus, Type 2, Tobacco Smoke Pollution, Prospective Studies, Databases, Factual