Prodrugs of sulfide and persulfide species: Implications in their different pharmacological activities.

Zhengnan Yuan, Xiaoxiao Yang, Binghe Wang, Bingchen Yu

Journal: Current opinion in chemical biology 2023;75():102329

PMID: 37279623

Full Text on Elsevier Science View on PubMed

Abstract

Reactive sulfur species (RSS), such as HS, hydrogen polysulfide (HS, n ≥ 2), and hydropersulfides (RSSH, n ≥ 1), are known to mediate diverse signaling pathways and possess a plethora of exciting therapeutic opportunities. Historically, due to the rapid inter-conversion among those species in vivo, the biological differences of distinct sulfur species were often overlooked. These species were considered to enrich the global sulfur pool in almost an equal fashion. However, advancement in this field has revealed that sulfur species at different oxidation states result in different pharmacological effects including scavenging reactive oxygen species (ROS), activating ion channels, and exhibiting analgesic effects. Here, we summarize recent advances in studying the biological and pharmacological differences of distinct sulfur species; discuss this phenomenon from the view of chemical properties and sulfur signaling pathways; and lay out a roadmap to transforming such new knowledge into general principles in developing sulfur-based therapeutics.

Address: Department of Chemistry, Georgia State University, Atlanta, GA 30303, USA. Electronic address: [email protected].; Department of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA 30303, USA.; Department of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA 30303, USA. Electronic address: [email protected].

DOI: 10.1016/j.cbpa.2023.102329

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MeSH Terms: Hydrogen Sulfide, Prodrugs, Sulfides, Sulfur