Nascent Proteomics: Chemical Tools for Monitoring Newly Synthesized Proteins.

Qi Tang, Xing Chen

Journal: Angewandte Chemie (International ed. in English) 2023;62(40):e202305866

PMID: 37309018

Abstract

Cellular proteins are dynamically regulated in response to environmental stimuli. Conventional proteomics compares the entire proteome in different cellular states to identify differentially expressed proteins, which suffers from limited sensitivity for analyzing acute and subtle changes. To address this challenge, nascent proteomics has been developed, which selectively analyzes the newly synthesized proteins, thus offering a more sensitive and timely insight into the dynamic changes of the proteome. In this Minireview, we discuss recent advancements in nascent proteomics, with an emphasis on methodological developments. Also, we delve into the current challenges and provide an outlook on the future prospects of this exciting field.

Address: College of Chemistry and Molecular Engineering, Beijing National Laboratory for Molecular Sciences, Peking University, Beijing, 100871, China.; College of Chemistry and Molecular Engineering, Peking-Tsinghua Center for Life Science, Beijing National Laboratory for Molecular Sciences, Synthetic and Functional Biomolecules Center, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Peking University, Beijing, 100871, China.

DOI: 10.1002/anie.202305866

Link outs

Subscription / membership required

Full Text Sources:

https://doi.org/10.1002/anie.202305866

MeSH Terms: Proteome, Proteomics