Surgically Correctable Congenital Anomalies: Reducing Morbidity and Mortality in the First 8000 Days of Life.

Tahmina Banu, Shilpa Sharma, Tanvir Kabir Chowdhury, Tasmiah Tahera Aziz, Benjamin Martin, Justina O Seyi-Olajide, Emmanuel Ameh, Doruk Ozgediz, Kokila Lakhoo, Stephen W Bickler, John G Meara, Donald Bundy, Dean T Jamison, Greg Klazura, Alicia Sykes, Ava Yap, Godfrey Sama Philipo

Journal: World journal of surgery 2023;47(12):3408-3418

PMID: 37311874

Abstract

BACKGROUND

Congenital anomalies are a leading cause of morbidity and mortality worldwide. We aimed to review the common surgically correctable congenital anomalies with recent updates on the global disease burden and identify the factors affecting morbidity and mortality.

METHOD

A literature review was done to assess the burden of surgical congenital anomalies with emphasis on those that present within the first 8000 days of life. The various patterns of diseases were analyzed in both low- and middle-income countries (LMIC) and high-income countries (HIC).

RESULTS

Surgical problems such as digestive congenital anomalies, congenital heart disease and neural tube defects are now seen more frequently. The burden of disease weighs more heavily on LMIC. Cleft lip and palate has gained attention and appropriate treatment within many countries, and its care has been strengthened by global surgical partnerships. Antenatal scans and timely diagnosis are important factors affecting morbidity and mortality. The frequency of pregnancy termination following prenatal diagnosis of a congenital anomaly is lower in many LMIC than in HIC.

CONCLUSION

Congenital heart disease and neural tube defects are the most common congenital surgical diseases; however, easily treatable gastrointestinal anomalies are underdiagnosed due to the invisible nature of the condition. Current healthcare systems in most LMICs are still unprepared to tackle the burden of disease caused by congenital anomalies. Increased investment in surgical services is needed.

© 2023. The Author(s) under exclusive licence to Société Internationale de Chirurgie.

Address: Chittagong Research Institute for Children Surgery (CRICS), Panchlaish, Chittagong, 4203, Bangladesh. [email protected].; Department of Pediatric Surgery, All India Institute of Medical Sciences, New Delhi, India.; Department of Pediatric Surgery, Chittagong Medical College and Hospital (CMCH), Chittagong, Bangladesh.; Chittagong Research Institute for Children Surgery (CRICS), Panchlaish, Chittagong, 4203, Bangladesh.; Department of Paediatric Surgery and Urology, Bristol Children's Hospital, Bristol, UK.; Pediatric Surgery Unit, Lagos University Teaching Hospital, Lagos, Nigeria.; Division of Pediatric Surgery, Department of Surgery, National Hospital, Abuja, Nigeria.; Division of Pediatric Surgery, Department of Surgery, University of California San Francisco, San Francisco, CA, USA.; Department of Paediatric Surgery, University of Oxford and Oxford University Hospitals, Oxford, UK.; Division of Pediatric Surgery, Department of Surgery, University of California San Diego School of Medicine, 9500 Gilman Drive #0739, La Jolla, San Diego, CA, 92093-0739, USA.; Program in Global Surgery and Social Change, Harvard Medical School, Boston, MA, USA.; Global Research Consortium for School Health and Nutrition, London School of Hygiene and Tropical Medicine, London, UK.; Institute for Global Health Sciences, University of California, San Francisco, San Francisco, CA, USA.; Loyola University Medical Center, Chicago, IL, USA.; Naval Medical Center San Diego, San Diego, CA, USA.; Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
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