Naringenin: A flavanone with anti-inflammatory and anti-infective properties.

Ji Cai, Hongli Wen, He Zhou, Dan Zhang, Dongfeng Lan, Songpo Liu, Chunyang Li, Xiaofang Dai, Tao Song, Xianyao Wang, Yuqi He, Zhixu He, Jun Tan, Jidong Zhang

Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023;164():114990

PMID: 37315435

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Abstract

Although a growing body of research has recently shown how crucial inflammation and infection are to all major diseases, several of the medications currently available on the market have various unfavourable side effects, necessitating the development of alternative therapeutic choices. Researchers are increasingly interested in alternative medications or active components derived from natural sources. Naringenin is a commonly consumed flavonoid found in many plants, and since it was discovered to have nutritional benefits, it has been utilized to treat inflammation and infections caused by particular bacteria or viruses. However, the absence of adequate clinical data and naringenin's poor solubility and stability severely restrict its usage as a medicinal agent. In this article, we discuss naringenin's effects and mechanisms of action on autoimmune-induced inflammation, bacterial infections, and viral infections based on recent research. We also present a few suggestions for enhancing naringenin's solubility, stability, and bioavailability. This paper emphasizes the potential use of naringenin as an anti-inflammatory and anti-infective agent and the next prophylactic substance for the treatment of various inflammatory and infectious diseases, even though some mechanisms of action are still unclear, and offers some theoretical support for its clinical application.

Address: Department of Immunology, Zunyi Medical University, Zunyi 563000, China; Special Key Laboratory of Gene Detection & Therapy of Guizhou Province, Zunyi Medical University, Zunyi 563000, China. Electronic address: [email protected].; Department of Immunology, Zunyi Medical University, Zunyi 563000, China. Electronic address: [email protected].; Department of Immunology, Zunyi Medical University, Zunyi 563000, China; Special Key Laboratory of Gene Detection & Therapy of Guizhou Province, Zunyi Medical University, Zunyi 563000, China. Electronic address: [email protected].; Zunyi Medical University Library, Zunyi 563000, China. Electronic address: [email protected].; Department of Immunology, Zunyi Medical University, Zunyi 563000, China; Special Key Laboratory of Gene Detection & Therapy of Guizhou Province, Zunyi Medical University, Zunyi 563000, China. Electronic address: [email protected].; Department of Immunology, Zunyi Medical University, Zunyi 563000, China; Special Key Laboratory of Gene Detection & Therapy of Guizhou Province, Zunyi Medical University, Zunyi 563000, China. Electronic address: [email protected].; Department of Immunology, Zunyi Medical University, Zunyi 563000, China; Special Key Laboratory of Gene Detection & Therapy of Guizhou Province, Zunyi Medical University, Zunyi 563000, China. Electronic address: [email protected].; Department of Immunology, Zunyi Medical University, Zunyi 563000, China; Special Key Laboratory of Gene Detection & Therapy of Guizhou Province, Zunyi Medical University, Zunyi 563000, China. Electronic address: [email protected].; Department of Immunology, Zunyi Medical University, Zunyi 563000, China; Special Key Laboratory of Gene Detection & Therapy of Guizhou Province, Zunyi Medical University, Zunyi 563000, China. Electronic address: [email protected].; Department of Immunology, Zunyi Medical University, Zunyi 563000, China; Special Key Laboratory of Gene Detection & Therapy of Guizhou Province, Zunyi Medical University, Zunyi 563000, China. Electronic address: [email protected].; School of Pharmacy, Zunyi Medical University, Zunyi 563000, China. Electronic address: [email protected].; Collaborative Innovation Center of Tissue Damage Repair and Regeneration Medicine, Zunyi Medical University, Zunyi 563000, China. Electronic address: [email protected].; Department of Histology and Embryology, Zunyi Medical University, Zunyi 563000, China. Electronic address: [email protected].; Department of Immunology, Zunyi Medical University, Zunyi 563000, China; Special Key Laboratory of Gene Detection & Therapy of Guizhou Province, Zunyi Medical University, Zunyi 563000, China; Collaborative Innovation Center of Tissue Damage Repair and Regeneration Medicine, Zunyi Medical University, Zunyi 563000, China. Electronic address: [email protected].

DOI: 10.1016/j.biopha.2023.114990

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MeSH Terms: Humans, Flavanones, Anti-Inflammatory Agents, Inflammation, Anti-Infective Agents