Reversing the mitochondrial hex that bewitches NLRP3.

Manasa Mellacheruvu, Grace M E P Lawrence, Stefan Emming, Kate Schroder

Journal: Science immunology 2023;8(84):eadh2967

PMID: 37327323

Abstract

Hexokinase dissociation from mitochondria triggers calcium-induced oligomerization of VDAC within the outer mitochondrial membrane, leading to NLRP3 recruitment and inflammasome signaling (see related Research Article by Baik ).

Address: Institute for Molecular Bioscience, University of Queensland, St Lucia, QLD, Australia.

DOI: 10.1126/sciimmunol.adh2967

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MeSH Terms: NLR Family, Pyrin Domain-Containing 3 Protein, Mitochondria, Mitochondrial Membranes, Inflammasomes, Signal Transduction