Navigating the boundaries between metabolism and epigenetics in trypanosomes.

Ana Paula Menezes, Ana Milena Murillo, Camila Gachet de Castro, Natalia Karla Bellini, Luiz Ricardo Orsini Tosi, Otavio Henrique Thiemann, Maria Carolina Elias, Ariel Mariano Silber, Julia Pinheiro Chagas da Cunha

Journal: Trends in parasitology 2023;39(8):682-695

PMID: 37349193

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Abstract

Epigenetic marks enable cells to acquire new biological features that favor their adaptation to environmental changes. These marks are chemical modifications on chromatin-associated proteins and nucleic acids that lead to changes in the chromatin landscape and may eventually affect gene expression. The chemical tags of these epigenetic marks are comprised of intermediate cellular metabolites. The number of discovered associations between metabolism and epigenetics has increased, revealing how environment influences gene regulation and phenotype diversity. This connection is relevant to all organisms but underappreciated in digenetic parasites, which must adapt to different environments as they progress through their life cycles. This review speculates and proposes associations between epigenetics and metabolism in trypanosomes, which are protozoan parasites that cause human and livestock diseases.

Address: Laboratório de Ciclo Celular - Instituto Butantan, São Paulo-SP, Brazil; Centro de Toxinas, Resposta Imune e Sinalização Celular (CeTICS), Instituto Butantan, São Paulo, Brazil.; Laboratório de Bioquímica de Tryps - LabTryps, Departamento de Parasitologia, Universidade de São Paulo, São Paulo-SP, Brazil.; Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto-SP, Brazil.; Instituto de Física de São Carlos, Universidade de São Paulo, São Carlos-SP, Brazil.; Laboratório de Bioquímica de Tryps - LabTryps, Departamento de Parasitologia, Universidade de São Paulo, São Paulo-SP, Brazil. Electronic address: [email protected].; Laboratório de Ciclo Celular - Instituto Butantan, São Paulo-SP, Brazil; Centro de Toxinas, Resposta Imune e Sinalização Celular (CeTICS), Instituto Butantan, São Paulo, Brazil. Electronic address: [email protected].

DOI: 10.1016/j.pt.2023.05.010

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MeSH Terms: Humans, Epigenesis, Genetic, Chromatin, Trypanosoma