Pathogenic role of S100 proteins in psoriasis.

Huifang Liang, Junqin Li, Kaiming Zhang

Journal: Frontiers in immunology 2023;14():1191645

PMID: 37346040

Free Full Text on PubMed Central View on PubMed

Abstract

Psoriasis is a chronic inflammatory skin disease. The histopathological features of psoriasis include excessive proliferation of keratinocytes and infiltration of immune cells. The S100 proteins are a group of EF-hand Ca-binding proteins, including S100A2, -A7, -A8/A9, -A12, -A15, which expression levels are markedly upregulated in psoriatic skin. These proteins exert numerous functions such as serving as intracellular Ca sensors, transduction of Ca signaling, response to extracellular stimuli, energy metabolism, and regulating cell proliferation and apoptosis. Evidence shows a crucial role of S100 proteins in the development and progress of inflammatory diseases, including psoriasis. S100 proteins can possibly be used as potential therapeutic target and diagnostic biomarkers. This review focuses on the pathogenic role of S100 proteins in psoriasis.

Address: ShanXi Key Laboratory of Stem Cells for Immunological Dermatosis, Institute of Dermatology, Taiyuan City Center Hospital, Taiyuan, China.; State Key Breeding Laboratory of Stem Cells for Immunological Dermatosis, Institute of Dermatology, Taiyuan City Center Hospital, Taiyuan, China.

DOI: 10.3389/fimmu.2023.1191645

Link outs

Free resources

Full Text Sources:

Medical:

https://medlineplus.gov/psoriasis.html

Miscellaneous:

https://assays.cancer.gov/CPTAC-1453

Research Materials:

https://antibodies.cancer.gov/detail/CPTC-S100A2-1

MeSH Terms: Humans, S100 Proteins, S100 Calcium Binding Protein A7, Psoriasis, Skin, Keratinocytes