RORing toward immunoregulation in glomerulonephritis?

Chunni Lu, A Richard Kitching

Journal: Kidney international 2023;104(1):28-31

PMID: 37349057

Full Text on Elsevier Science View on PubMed

Abstract

CD4 T cells that express forkhead box protein 3 are important in maintaining tolerance and restraining effector responses. Herrnstadt et al. use a model of rapidly progressive glomerulonephritis to examine the nature and role of forkhead box protein 3-positive and retinoid acid-related orphan receptor γt-positive regulatory T cells. These cells are prominent in experimental glomerulonephritis, both locally and systemically, and are present in kidneys of people with anti-neutrophil cytoplasmic antibody-associated vasculitis. Functionally, despite their expression of retinoid acid-related orphan receptor γt, associated with T-helper cell 17 cells, they regulate cellular immunity, both systemically and within the kidney.

Address: Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, Monash University, Clayton, Victoria, Australia.; Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, Monash University, Clayton, Victoria, Australia; Department of Nephrology, Monash Health, Clayton, Victoria, Australia; Department of Pediatric Nephrology, Monash Health, Clayton, Victoria, Australia. Electronic address: [email protected].

DOI: 10.1016/j.kint.2023.04.018

Link outs

Free resources

Research Materials:

https://antibodies.cancer.gov/detail/CPTC-CD4-1

Subscription / membership required

Full Text Sources:

https://linkinghub.elsevier.com/retrieve/pii/S0085...

MeSH Terms: Humans, Glomerulonephritis, Kidney, T-Lymphocytes, Regulatory, Forkhead Transcription Factors, Retinoids