Four uncommon clinical fungi, Lodderomyces elongisporus, Kodamaea ohmeri, Cyberlindnera fabianii and Wickerhamomyces anomalus, isolated in superficial samples from Côte d'Ivoire.

Ama Valérie Bonouman Ira, Donika Krasteva, Francis Kouadjo, Fréderic Roger, Virginie Bellet, David Koffi, Cyrille Pottier, Offianan André Toure, Pascal Drakulovski, Aliko Joseph Djaman, Stéphane Ranque, Sébastien Bertout

Journal: Journal de mycologie medicale 2023;33(3):101410

PMID: 37356368

Full Text on Elsevier Science View on PubMed

Abstract

AIMS

The rare yeast species Lodderomyces elongisporus, Kodamaea ohmeri, Cyberlindnera fabianii, and Wickerhamomyces anomalus are increasingly implicated in severe mycoses in immunocompromised patients. This study aimed to assess the prevalence of uncommon yeast species in Côte d'Ivoire.

METHODS

The yeast isolates from superficial samples, mainly vaginal swabs, were collected at the Pasteur Institute of Abidjan in a study on the molecular epidemiology of clinical yeast species. Identification relied on MALDI-TOF MS and ITS sequence analysis. Antifungal susceptibility testing was performed using the CLSI method.

RESULTS

Of the 315 strains analysed from 227 outpatients, 14 belonged to 4 uncommon species: Lodderomyces elongisporus, Kodamaea ohmeri, Cyberlindnera fabianii, and Wickerhamomyces anomalus. None exhibited elevated fluconazole, amphotericin B, caspofungin, ketoconazole, or flucytosin MIC.

CONCLUSIONS

The presence of these rare yeasts represents a risk in immunocompromised people. Their adequate and timely identification is a priority. Overall, enhancing the mycoses diagnostic capacities in Côte d'Ivoire, and more generally in African clinical laboratories with limited resources is a critical aim.

Address: UMI 233, TransVIHMI, UM-IRD-INSERM U1175, Laboratoire de Parasitologie Mycologie, Faculté de Pharmacie, Université de Montpellier, Montpellier 34090, France; Institut Pasteur de Côte d'Ivoire, BP 490, Abidjan, Cote d'Ivoire. Electronic address: [email protected].; UMI 233, TransVIHMI, UM-IRD-INSERM U1175, Laboratoire de Parasitologie Mycologie, Faculté de Pharmacie, Université de Montpellier, Montpellier 34090, France.; Institut Pasteur de Côte d'Ivoire, BP 490, Abidjan, Cote d'Ivoire.; Institut Hospitalo-Universitaire Méditerranée Infection,Marseille 13005 , France; IRD, AP-HM, SSA, VITROME, Aix-Marseille Université, Marseille 13007, France.

DOI: 10.1016/j.mycmed.2023.101410

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MeSH Terms: Yeasts, Fungi, Female, Humans, Mycoses, Cote d'Ivoire, Saccharomycetales