Posterior Herpetic Uveitis: A Comprehensive Review.

Andrea Servillo, Alessandro Berni, Alessandro Marchese, Bahram Bodaghi, Moncef Khairallah, Russell W Read, Elisabetta Miserocchi

Journal: Ocular immunology and inflammation 2023;31(7):1461-1472

PMID: 37364039

Abstract

PURPOSE

To report and illustrate the main clinical presentations of posterior herpetic uveitis.

METHODS

Narrative review.

RESULTS

The ocular manifestations of posterior herpetic uveitis include different clinical presentations. Herpes simplex and varicella zoster can cause acute retinal necrosis, progressive outer retinal necrosis, and non-necrotizing herpetic retinopathies. Cytomegalovirus has been associated with fulminant retinitis with confluent areas of retinal necrosis and retinal hemorrhages, indolent/granular retinitis, and frosted branch angiitis. These diverse clinical presentations are often associated with specific risk factors and different immunological profiles of the host.

CONCLUSIONS

Herpetic viruses can cause posterior uveitis, presenting various clinical findings. Specific ocular manifestations and the immunological status of the host can help to differentiate the various herpetic entities before laboratory tests confirm the diagnosis.

Address: Department of Ophthalmology, IRCCS San Raffaele Scientific Institute, Milan, Italy.; School of Medicine, Vita-Salute San Raffaele University, Milan, Italy.; Department of Ophthalmology, Pitié-Salpêtrière Hospital, Paris, France.; Department of Ophthalmology, Fattouma Bourguiba University Hospital, Faculty of Medicine, University of Monastir, Monastir, Tunisia.; Department of Ophthalmology, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama, USA.

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