The multifaceted nature of peroxiredoxins in chemical biology.

Sebastián F Villar, Gerardo Ferrer-Sueta, Ana Denicola

Journal: Current opinion in chemical biology 2023;76():102355

PMID: 37385138

Full Text on Elsevier Science View on PubMed

Abstract

Peroxiredoxins (Prx), thiol-dependent peroxidases, were first identified as HO detoxifiers, and more recently as HO sensors, intermediates in redox-signaling pathways, metabolism modulators, and chaperones. The multifaceted nature of Prx is not only dependent on their peroxidase activity but also strongly associated with specific protein-protein interactions that are being identified, and where the Prx oligomerization dynamics plays a role. Their oxidation by a peroxide substrate forms a sulfenic acid that opens a route to channel the redox signal to diverse protein targets. Recent research underscores the importance of different Prx isoforms in the cellular processes behind disease development with potential therapeutic applications.

Address: Laboratorio de Fisicoquímica Biológica, Instituto de Química Biológica, Facultad de Ciencias, Montevideo, Uruguay; Centro de Investigaciones Biomédicas (CEINBIO), Universidad de la República, Montevideo, Uruguay.; Laboratorio de Fisicoquímica Biológica, Instituto de Química Biológica, Facultad de Ciencias, Montevideo, Uruguay; Centro de Investigaciones Biomédicas (CEINBIO), Universidad de la República, Montevideo, Uruguay. Electronic address: [email protected].

DOI: 10.1016/j.cbpa.2023.102355

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MeSH Terms: Peroxiredoxins, Hydrogen Peroxide, Peroxides, Antioxidants, Oxidation-Reduction, Biology