NAADP-binding proteins - Linking NAADP signaling to cancer and immunity.

Louisa D Heßling, Berit Troost-Kind, Mariella Weiß

Journal: Biochimica et biophysica acta. Molecular cell research 2023;1870(7):119531

PMID: 37394011

Free Full Text on Elsevier Science View on PubMed

Abstract

NAADP is one of the most potent calcium mobilizing second messengers. Only recently, two NAADP-binding proteins have been identified: HN1L/JPT2 and LSM12. Further, ASPDH was suggested as a less selective binding partner. Apart from this newly uncovered link, little is known about the shared mechanisms between these proteins. The aim of this review is to assess potential functional connections between NAADP and its binding proteins. We here give a description of two major links. For one, HN1L/JPT2 and LSM12 both have potent oncogenic functions in several cancer types. Second, they are involved in similar cellular pathways in both cancer and immunity.

Address: The Calcium Signaling Group, Dept. of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany. Electronic address: [email protected].; The Calcium Signaling Group, Dept. of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.

DOI: 10.1016/j.bbamcr.2023.119531

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MeSH Terms: Humans, Carrier Proteins, Second Messenger Systems, Signal Transduction, NADP, Neoplasms