Emerging roles of the MiT/TFE factors in cancer.

Roberto Zoncu, Rushika M Perera

Journal: Trends in cancer 2023;9(10):817-827

PMID: 37400313

Full Text on Elsevier Science View on PubMed

Abstract

The microphthalmia/transcription factor E (MiT/TFE) transcription factors (TFs; TFEB, TFE3, MITF, and TFEC) play a central role in cellular catabolism and quality control and are subject to extensive layers of regulation that influence their localization, stability, and activity. Recent studies have highlighted a broader role for these TFs in driving diverse stress-adaptation pathways, which manifest in a context- and tissue-dependent manner. Several human cancers upregulate the MiT/TFE factors to survive extreme fluctuations in nutrients, energy, and pharmacological challenges. Emerging data suggest that reduced activity of the MiT/TFE factors can also promote tumorigenesis. Here, we outline recent findings relating to novel mechanisms of regulation and activity of MiT/TFE proteins across some of the most aggressive human cancers.

Address: Department of Molecular and Cellular Biology, University of California at Berkeley, Berkeley, CA 94720, USA. Electronic address: [email protected].; Department of Anatomy, University of California San Francisco, San Francisco, CA 94143, USA; Department of Pathology, University of California San Francisco, San Francisco, CA 94143, USA; Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA 94158, USA. Electronic address: [email protected].

DOI: 10.1016/j.trecan.2023.06.005

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MeSH Terms: Humans, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, Microphthalmia-Associated Transcription Factor, Microphthalmos, Lysosomes, Neoplasms