Biocompatible anti-aging face mask prepared with curcumin and natural rubber with antioxidant properties.

Neda Farhadi, Rondinelli Donizetti Herculano, Marcos Roberto Cardoso, Maria José Soares Mendes-Giannini, Vadim Jucaud, Mehmet Remzi Dokmeci, Ana Marisa Fusco-Almeida, Bingbing Li, Fernando Lucas Primo, Andressa Machado Farias, Shuyi Huang, Alejandro Gómez, Flávio Kunert de Souza Silva, Guilherme Ferreira Caetano, Ricardo José de Mendonça, Juliana Ferreira Floriano, Nayrim Brizuela Guerra, Ana Paula de Sousa Abreu, Josana Carla da Silva Sasaki, Mateus Scontri, Cassamo Ussemane Mussagy, Giovana Sant'Ana Pegorin Brasil, Mariza Aires Fernandes, Caroline Barcelos Costa-Orlandi

Journal: International journal of biological macromolecules 2023;242(Pt 1):124778

PMID: 37172704

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Abstract

Natural rubber latex (NRL) is a biopolymer widely used in biomedical applications. In this work, we propose an innovative cosmetic face mask, combining the NRL's biological properties with curcumin (CURC), which has a high level of antioxidant activity (AA) to provide anti-aging benefits. Chemical, mechanical and morphological characterizations were performed. The CURC released by the NRL was evaluated by permeation in Franz cells. Cytotoxicity and hemolytic activity assays were performed to assess safety. The findings showed that the biological properties of CURC were preserved after loading in the NRL. About 44.2 % of CURC was released within the first six hours, and in vitro permeation showed that 9.36 % ± 0.65 was permeated over 24h. CURC-NRL was associated with a metabolic activity higher than 70 % in 3 T3 fibroblasts, cell viability ≥95 % in human dermal fibroblasts, and a hemolytic rate ≤ 2.24 % after 24 h. Furthermore, CURC-NRL maintained the mechanical characteristics (range suitable) for human skin application. We observed that CURC-NRL preserved ~20 % antioxidant activity from curcumin-free after loading in the NRL. Our results suggest that CURC-NRL has the potential to be used in the cosmetics industry, and the experimental methodology utilized in this study can be applied to different kinds of face masks.

Address: Bioengineering & Biomaterials Group, São Paulo State University (UNESP), School of Pharmaceutical Sciences, Km 01 Araraquara-Jaú Road, Araraquara, São Paulo, Brazil; Department of Clinical Analysis, São Paulo State University (UNESP), School of Pharmaceutical Sciences, Km 01 Araraquara-Jaú Road, Araraquara, São Paulo, Brazil.; Department of Clinical Analysis, São Paulo State University (UNESP), School of Pharmaceutical Sciences, Km 01 Araraquara-Jaú Road, Araraquara, São Paulo, Brazil.; Bionanomaterials and Bioengineering Group, Department of Biotechnology and Bioprocesses Engineering, São Paulo State University (UNESP), Faculty of Pharmaceutical Sciences, Araraquara, 14800-903, São Paulo, Brazil.; Bioengineering & Biomaterials Group, São Paulo State University (UNESP), School of Pharmaceutical Sciences, Km 01 Araraquara-Jaú Road, Araraquara, São Paulo, Brazil.; Escuela de Agronomía, Facultad de Ciencias Agronómicas y de los Alimentos, Pontificia Universidad Católica de Valparaíso, Chile.; Science Faculty, São Paulo State University (UNESP), Bauru, São Paulo 17033-360, Brazil.; São Paulo State University (UNESP), Botucatu Medical School, Botucatu, São Paulo 18.618-687, Brazil; National Heart and Lung Institute, Imperial College London, London, UK.; Department of Biochemistry, Pharmacology and Physiology, Federal University of Triangulo Mineiro (UFTM), Uberaba, Minas Gerais, Brazil.; University Center of Hermínio Ometto Foundation (FHO), Araras, São Paulo, Brazil; Division of Dermatology, Department of Internal Medicine, São Paulo University (USP), Ribeirão Preto Medical School, Ribeirão Preto, SP, Brazil.; Terasaki Institute for Biomedical Innovation (TIBI), 11507 West Olympic Blvd, Los Angeles, CA, USA.; Terasaki Institute for Biomedical Innovation (TIBI), 11507 West Olympic Blvd, Los Angeles, CA, USA; Autonomy Research Center for STEAHM (ARCS), California State University, Northridge, CA 91324, USA.; São Paulo State University (UNESP), School of Sciences and Languages of Assis, Department of Biotechnology, Assis, São Paulo 19806-900, Brazil.; São Carlos Institute of Physics, University of São Paulo, PO Box 369, 13561-970 São Carlos, SP, Brazil.; Bioengineering & Biomaterials Group, São Paulo State University (UNESP), School of Pharmaceutical Sciences, Km 01 Araraquara-Jaú Road, Araraquara, São Paulo, Brazil; Terasaki Institute for Biomedical Innovation (TIBI), 11507 West Olympic Blvd, Los Angeles, CA, USA; Autonomy Research Center for STEAHM (ARCS), California State University, Northridge, CA 91324, USA. Electronic address: [email protected].

DOI: 10.1016/j.ijbiomac.2023.124778

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MeSH Terms: Humans, Rubber, Antioxidants, Masks, Curcumin, Aging