Dietary exposure to endocrine disruptors in gut microbiota: A systematic review.

Laura Calero-Medina, Maria Jose Jimenez-Casquet, Leticia Heras-Gonzalez, Javier Conde-Pipo, Alejandro Lopez-Moro, Fatima Olea-Serrano, Miguel Mariscal-Arcas

Journal: The Science of the total environment 2023;886():163991

PMID: 37169193

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Abstract

Endocrine disrupting chemicals (EDCs) can interfere with hormonal actions and have been associated with a higher incidence of metabolic disorders. They affect numerous physiological, biochemical, and endocrinal activities, including reproduction, metabolism, immunity, and behavior. The purpose of this review was to elucidate the association of EDCs in food with the gut microbiota and with metabolic disorders. EDC exposure induces changes that can lead to microbial dysbiosis. Products and by-products released by the microbial metabolism of EDCs can be taken up by the host. Changes in the composition of the microbiota and production of microbial metabolites may have a major impact on the host metabolism.

Address: Department of Nutrition and Food Science, School of Pharmacy, University of Granada, 18071 Granada, Spain.; Virgen de las Nieves University Hospital, Granada, Spain; Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA), Granada, Spain.; Department of Nutrition and Food Science, School of Pharmacy, University of Granada, 18071 Granada, Spain; Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA), Granada, Spain. Electronic address: [email protected].

DOI: 10.1016/j.scitotenv.2023.163991

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Full Text Sources:

https://linkinghub.elsevier.com/retrieve/pii/S0048...

Medical:

https://medlineplus.gov/metabolicdisorders.html

MeSH Terms: Humans, Endocrine Disruptors, Dietary Exposure, Gastrointestinal Microbiome, Reproduction, Metabolic Diseases