Gianfranco Pintus, Babagana Modu, Ahmad Faizal Abdull Razis, Oksana Sytar, Lorene Armstrong, Charles Oluwaseun Adetunji, Farukh Sharopov, Patrick Valere Tsouh Fokou, Ilkay Erdogan Orhan, Soheb Anwar Mohammed, Javad Sharifi-Rad, Roberta Giordo, Anna Maria Posadino, William C Cho, Solomon Habtemariam, Alibek Ydyrys, Zehra Gulsunoglu-Konuskan, Miquel Martorell, Daniela Calina
Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023;163():114866
PMID: 37182516
Artemisinin (ART) is a bioactive compound isolated from the plant Artemisia annua and has been traditionally used to treat conditions such as malaria, cancer, viral infections, bacterial infections, and some cardiovascular diseases, especially in Asia, North America, Europe and other parts of the world. This comprehensive review aims to update the biomedical potential of ART and its derivatives for treating human diseases highlighting its pharmacokinetic and pharmacological properties based on the results of experimental pharmacological studies in vitro and in vivo. Cellular and molecular mechanisms of action, tested doses and toxic effects of artemisinin were also described. The analysis of data based on an up-to-date literature search showed that ART and its derivatives display anticancer effects along with a wide range of pharmacological activities such as antibacterial, antiviral, antimalarial, antioxidant and cardioprotective effects. These compounds have great potential for discovering new drugs used as adjunctive therapies in cancer and various other diseases. Detailed translational and experimental studies are however needed to fully understand the pharmacological effects of these compounds.
Copyright © 2023 The Authors. Published by Elsevier Masson SAS.. All rights reserved.
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