Role of MAGI2-AS3 in malignant and non-malignant disorders.

Mohammad Taheri, Arian Askari, Bashdar Mahmud Hussen, Soudeh Ghafouri-Fard, Fariborz Rashnoo

Journal: Pathology, research and practice 2023;246():154530

PMID: 37196468

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Abstract

MAGI2 Antisense RNA 3 (MAGI2-AS3) is a long non-coding RNA (lncRNA) transcribed from a locus on 7q21.11. This lncRNA has been described to be abnormally expressed in a variety of malignancies in correlation with many clinical characteristics. Moreover, it might participate in the pathogenesis of congenital diaphragmatic hernia, Alzheimer's disease and intervertebral disc degeneration. Mechanistically, MAGI2-AS3 can serve as a molecular sponge for miR-142-3p, miR-424-5p, miR-15b, miR-233, miR-452-5p, miR-629-5p, miR-25, miR-155, miR-23a-3p, miR-519c-3p, miR-374b-5p, miR-374a, miR-31-5p, miR-3163, miR-525-5p, miR-15-5p, miR-374a-5p, miR-374b-5p, miR-218-5p, miR-141-3p and miR-200a-3p to regulate expression of their mRNA targets. The current review summarizes the role of MAGI2-AS3 in different disorders to highlight its importance in their pathophysiology.

Address: Institute of Human Genetics, Jena University Hospital, Jena, Germany; Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran.; Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran.; Department of Clinical Analysis, College of Pharmacy, Hawler Medical University, Kurdistan Region, Iraq.; Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran. Electronic address: [email protected].; Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran. Electronic address: [email protected].

DOI: 10.1016/j.prp.2023.154530

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MeSH Terms: Humans, Adaptor Proteins, Signal Transducing, Cell Proliferation, Guanylate Kinases, MicroRNAs, RNA, Long Noncoding, RNA, Antisense