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Iron deficiency and its epigenetic effects on iron homeostasis.

Bashar Farida, Kasimu G Ibrahim, Bilyaminu Abubakar, Ibrahim Malami, Muhammad B Bello, Murtala B Abubakar, Abdullahi Y Abbas, Mustapha U Imam

Journal: Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) 2023;78():127203

PMID: 37201368

Full Text on Elsevier Science View on PubMed

Abstract

Iron deficiency is a common micronutrient deficiency associated with metabolic changes in the levels of iron regulatory proteins, hepcidin and ferroportin. Studies have associated dysregulation of iron homeostasis to other secondary and life-threatening diseases including anaemia, neurodegeneration and metabolic diseases. Iron deficiency plays a critical role in epigenetic regulation by affecting the Fe/α-ketoglutarate-dependent demethylating enzymes, Ten Eleven Translocase 1-3 (TET 1-3) and Jumonji-C (JmjC) histone demethylase, which are involved in epigenetic erasure of the methylation marks on both DNA and histone tails, respectively. In this review, studies involving epigenetic effects of iron deficiency associated with dysregulation of TET 1-3 and JmjC histone demethylase enzyme activities on hepcidin/ferroportin axis are discussed.

Copyright © 2023 Elsevier GmbH. All rights reserved.

Address: Department of Biochemistry and Molecular Biology, Faculty of Sciences, Usmanu Danfodiyo University PMB, 2254 Sokoto, Nigeria; Centre for Advanced Medical Research and Training, Usmanu Danfodiyo University PMB, 2254 Sokoto, Nigeria. Electronic address: [email protected].; Department of Basic Medical and Dental Sciences, Faculty of Dentistry, Zarqa University, Zarqa 13110, Jordan; Department of Physiology, Faculty of Basic Medical Sciences, College of Health Sciences, Usmanu Danfodiyo University PMB, 2254 Sokoto, Nigeria; Centre for Advanced Medical Research and Training, Usmanu Danfodiyo University PMB, 2254 Sokoto, Nigeria.; Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, Usmanu Danfodiyo University PMB, 2254 Sokoto, Nigeria; Centre for Advanced Medical Research and Training, Usmanu Danfodiyo University PMB, 2254 Sokoto, Nigeria.; Department of Pharmacognosy and Ethnopharmacy, Faculty of Pharmaceutical Sciences, Usmanu Danfodiyo University PMB, 2254 Sokoto, Nigeria; Centre for Advanced Medical Research and Training, Usmanu Danfodiyo University PMB, 2254 Sokoto, Nigeria.; Department of Veterinary Microbiology, Faculty of Veterinary Medicine, Usmanu Danfodiyo University PMB, 2254 Sokoto, Nigeria; Centre for Advanced Medical Research and Training, Usmanu Danfodiyo University PMB, 2254 Sokoto, Nigeria.; Department of Physiology, Faculty of Basic Medical Sciences, College of Health Sciences, Usmanu Danfodiyo University PMB, 2254 Sokoto, Nigeria; Centre for Advanced Medical Research and Training, Usmanu Danfodiyo University PMB, 2254 Sokoto, Nigeria.; Department of Biochemistry and Molecular Biology, Faculty of Sciences, Usmanu Danfodiyo University PMB, 2254 Sokoto, Nigeria.; Department of Medical Biochemistry, Faculty of Basic Medical Sciences, College of Health Sciences, Usmanu Danfodiyo University PMB, 2254 Sokoto, Nigeria; Centre for Advanced Medical Research and Training, Usmanu Danfodiyo University PMB, 2254 Sokoto, Nigeria. Electronic address: [email protected].
DOI: 10.1016/j.jtemb.2023.127203

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MeSH Terms: Humans, Hepcidins, Epigenesis, Genetic, Iron Deficiencies, Histone Demethylases, Iron, Homeostasis
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