Association between genetic factors and molar-incisor hypomineralisation or hypomineralised second primary molar: A systematic review.

Raíssa da Silva Figueira, Francisco Wilker Mustafa Gomes Muniz, Lara Carvalho Costa, Marcoeli Silva de Moura, Lúcia de Fátima Almeida de Deus Moura, Bibiana Mello de Oliveira, Cacilda Castelo Branco Lima, Cassiano Kuchenbecker Rösing, Marina de Deus Moura de Lima

Journal: Archives of oral biology 2023;152():105716

PMID: 37210809

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Abstract

OBJECTIVE

To determine the association between genetic factors and molar-incisor hypomineralisation (MIH) and/or hypomineralised second primary molars by means of a systematic review.

DESIGN

A search was performed in Medline-PubMed, Scopus, Embase and Web of Science databases; manual search and search in gray literature were also performed. Selection of articles was performed independently by two researchers. A third examiner was involved in cases of disagreement. Data extraction was performed using an Excel® spreadsheet and independent analysis was performed for each outcome.

RESULTS

Sixteen studies were included. There was an association between MIH and genetic variants related to amelogenesis, immune response, xenobiotic detoxification and other genes. Moreover, interactions between amelogenesis and immune response genes, and SNPs in the aquaporin gene and vitamin D receptors were associated with MIH. Greater agreement of MIH was found in pairs of monozygotic twins than dizygotic twins. The heritability of MIH was 20 %. Hypomineralised second primary molars was associated with SNPs in the hypoxia-related HIF-1 gene and methylation in genes related to amelogenesis.

CONCLUSION

With very low or low certainty of evidence, an association was observed between MIH and SNPs in genes associated with amelogenesis, immune response, xenobiotic detox and ion transport. Interactions between genes related to amelogenesis and immune response as well as aquaporin genes were associated to MIH. With very low certainty of evidence, hypomineralised second primary molars was associated to a hypoxia-related gene and to methylation in genes related to amelogenesis. Moreover, higher agreement of MIH in pairs of monozygotic twins than dizygotic twins was observed.

Address: Department of Pathology and Dental Clinic, Federal University of Piauí, Teresina, Piauí, Brazil.; Department of Periodontology, Federal University of Pelotas, Pelotas, Rio Grande do Sul, Brazil.; Post Graduate Program in Genetics and Molecular Biology, Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil; Santa Casa de Misericórdia de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil.; Department of Periodontology, Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.; Department of Pathology and Dental Clinic, Federal University of Piauí, Teresina, Piauí, Brazil. Electronic address: [email protected].

DOI: 10.1016/j.archoralbio.2023.105716

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MeSH Terms: Humans, Dental Enamel Hypoplasia, Molar Hypomineralization, Xenobiotics, Amelogenesis, Molar, Prevalence