Odontoblast morphology and dental repair.

P E Murray, I About, P J Lumley, J-C Franquin, L J Windsor, A J Smith

Journal: Journal of dentistry 2009;31(1):75-82

PMID: 12615023

Full Text on Elsevier Science View on PubMed

Abstract

OBJECTIVES

To investigate the changes in morphology and activity of pulp odontoblasts in response to cavity restoration variables and patient factors.

METHODS

Class V non exposed cavities were prepared in the intact 1st or 2nd premolar teeth of 27 patients, aged between 9 and 17 years-old. Following tooth extraction, the area of reactionary dentine and the area of the odontoblasts were measured using computerised histomorphometry.

RESULTS

The cytoplasm to nucleus ratio of the odontoblasts was found to increase beneath cut dentinal tubules, following the secretion of reactionary dentine. However, none of the patient or preparation variables were found to be correlated with changes in the odontoblast cytoplasm to nucleus ratio.

CONCLUSIONS

Morphological changes in human odontoblasts is directly related to their capacity to repair dentine injuries and provide pulp protection. Changes in odontoblast morphology reflect secretory activity.

Address: Oral Biology, Indiana University School of Dentistry, Indianapolis, IN 46202-5186, USA. [email protected]

DOI: 10.1016/s0300-5712(02)00089-1

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MeSH Terms: Adolescent, Bicuspid, Calcium Hydroxide, Cell Nucleus, Child, Cytoplasm, Dental Amalgam, Dental Cavity Lining, Dental Cavity Preparation, Dental Pulp, Dental Restoration, Permanent, Dentin, Dentin, Secondary, Female, Humans, Male, Methylmethacrylates, Odontoblasts, Pulpitis, Time Factors, Zinc Oxide-Eugenol Cement