Mechanism of testicular injury induced by Di-ethylhexyl phthalate and its protective agents.

Yuxuan Lin, Wenqi Xu, Guang Yang, Ling Yang, Zhengguo Chen, Jianan Zhai, Qi Zhu, Zhifang Guo, Ningning Wang, Cong Zhang, Haoyuan Deng, Shaopeng Wang

Journal: Chemico-biological interactions 2023;381():110575

PMID: 37257576

Full Text on Elsevier Science View on PubMed

Abstract

["Di-ethylhexyl phthalate (DEHP) is used as an important plasticizer in a wide range of products such as paints, food packaging, medical devices and children's toys. In recent years, there has been increasing interest in the toxic effects of DEHP on the male reproductive organs, the testicles. Here, we reviewed the basic pathways of testicular damage caused by DEHP. The mechanism involves oxidative stress, ferroptosis, interfering with hypothalamic-pituitary-gonadal axis (HPGA) and testosterone level. We summarized the protective agents that have been shown to be effective in repairing this type of testicular damage in recent years. This provides a new perspective and direction for future research into the health effects and molecular mechanisms of DEHP.",{"copyright":"Copyright \u00a9 2023 Elsevier B.V. All rights reserved."}]

Address: Department of Food Nutrition and Safety, Dalian Medical University, No. 9W. Lushun South Road, Dalian, 116044, China.; Department of Cardiology, The First Affiliated Hospital of Dalian Medical University, Dalian, 116011, China. Electronic address: [email protected].; Department of Food Nutrition and Safety, Dalian Medical University, No. 9W. Lushun South Road, Dalian, 116044, China. Electronic address: [email protected].

DOI: 10.1016/j.cbi.2023.110575

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MeSH Terms: Child, Male, Humans, Diethylhexyl Phthalate, Testis, Phthalic Acids, Testicular Diseases, Protective Agents