Presence of Small-Conductance Calcium-Activated Potassium (SK) Channels in the Central and Peripheral Nervous Systems and Their Role in Health and Disease.

Marcos Fabio DosSantos, Lionete Gall Acosta Filha, Carla Pires Veríssimo, Carolina Kaminski Sanz, Parisa Gazerani

Journal: Journal of integrative neuroscience 2023;22(3):69

PMID: 37258451

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Abstract

["Potassium (K+) channels establish and maintain the resting potential of most living cells. Their activity is predominantly regulated by the membrane voltage or the K+ gradient across the cell membrane. However, many cells also express small-conductance calcium-activated potassium (SK) channels, which have the unique ability to translate changes in the level of the intracellular second messenger, Ca2+ to changes in the membrane K+ conductance and, therefore, the resting membrane potential. This article reviews the structure, presence, distribution, and function of SK channels, their pharmacological modulation, and their role in health and disease, emphasizing nociception and pain.",{"copyright":"\u00a9 2023 The Author(s). Published by IMR Press."}]

Address: Laboratório de Propriedades Mecânicas e Biologia Celular (PropBio), Departamento de Prótese e Materiais Dentários, Faculdade de Odontologia, Universidade Federal do Rio de Janeiro (UFRJ), RJ 21941-617 Rio de Janeiro, Brazil.; Laboratório de Morfogênese Celular (LMC), Instituto de Ciências Biomédicas (ICB), Universidade Federal do Rio de Janeiro (UFRJ), RJ 21941-590 Rio de Janeiro, Brazil.; Programa de Pós-Graduação em Neurociência Translacional, Instituto Nacional de Neurociência Translacional (INNT-UFRJ), RJ 21941-590 Rio de Janeiro, Brazil.; Programa de Pós-Graduação em Odontologia (PPGO), Universidade Federal do Rio de Janeiro (UFRJ), RJ 21941-617 Rio de Janeiro, Brazil.; Department of Life Sciences & Health, Faculty of Health Sciences, Oslo Metropolitan University, 0130 Oslo, Norway.; Department of Health Science & Technology, Faculty of Medicine, Aalborg University, 9260 Gistrup, Denmark.

DOI: 10.31083/j.jin2203069

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https://assays.cancer.gov/CPTAC-177

MeSH Terms: Calcium, Small-Conductance Calcium-Activated Potassium Channels, Potassium, Membrane Potentials, Peripheral Nervous System