Indispensable biomolecules for plant defense against pathogens: NBS-LRR and "nitrogen pool" alkaloids.

Qian Liu, Chunhong Zhang, Huiyong Fang, Letai Yi, Minhui Li

Journal: Plant science : an international journal of experimental plant biology 2023;334():111752

PMID: 37268110

Full Text on Elsevier Science View on PubMed

Abstract

In a complex natural environment, plants have evolved intricate and subtle defense response regulatory mechanisms for survival. Plant specific defenses, including the disease resistance protein nucleotide-binding site leucine-rich repeat (NBS-LRR) protein and metabolite derived alkaloids, are key components of these complex mechanisms. The NBS-LRR protein can specifically recognize the invasion of pathogenic microorganisms to trigger the immune response mechanism. Alkaloids, synthesized from amino acids or their derivatives, can also inhibit pathogens. This study reviews NBS-LRR protein activation, recognition, and downstream signal transduction in plant protection, as well as the synthetic signaling pathways and regulatory defense mechanisms associated with alkaloids. In addition, we clarify the basic regulation mechanism and summarize their current applications and the development of future applications in biotechnology for these plant defense molecules. Studies on the NBS-LRR protein and alkaloid plant disease resistance molecules may provide a theoretical foundation for the cultivation of disease resistant crops and the development of botanical pesticides.

Address: Inner Mongolia Hospital of Traditional Chinese Medicine, Hohhot, China; Baotou Medical College, Inner Mongolia Key Laboratory of Characteristic Geoherbs Resources Protection and Utilization, Inner Mongolia Engineering Research Center of The Planting and Development of Astragalus membranaceus of the Geoherbs, Baotou, China.; Baotou Medical College, Inner Mongolia Key Laboratory of Characteristic Geoherbs Resources Protection and Utilization, Inner Mongolia Engineering Research Center of The Planting and Development of Astragalus membranaceus of the Geoherbs, Baotou, China.; Hebei University of Chinese Medicine, Traditional Chinese Medicine Processing Technology Innovation Center of Hebei Province, Shijiazhuang, China. Electronic address: [email protected].; Inner Mongolia Medical University, Hohhot, China. Electronic address: [email protected].; Inner Mongolia Hospital of Traditional Chinese Medicine, Hohhot, China; Baotou Medical College, Inner Mongolia Key Laboratory of Characteristic Geoherbs Resources Protection and Utilization, Inner Mongolia Engineering Research Center of The Planting and Development of Astragalus membranaceus of the Geoherbs, Baotou, China; Inner Mongolia Institute of Traditional Chinese and Mongolian Medicine, Hohhot, China. Electronic address: [email protected].

DOI: 10.1016/j.plantsci.2023.111752

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MeSH Terms: Nucleotides, Disease Resistance, Plants, Binding Sites, Leucine-Rich Repeat Proteins, Plant Diseases, Plant Proteins