Kinetic Profile of Urine Metabolites after Acute Intake of a Phenolic Compounds-Rich Juice of Juçara ( Mart.) and Antioxidant Capacity in Serum and Erythrocytes: A Human Study.

["The ju\u00e7ara palm tree produces a small spherical and black-purple fruit similar to a\u00e7a\u00ed. It is rich in phenolic compounds, especially anthocyanins. A clinical trial evaluated the absorption and excretion of the main bioactive compounds in urine and the antioxidant capacity in serum and erythrocytes of 10 healthy subjects after ju\u00e7ara juice intake. Blood samples were collected before (0.0 h) and 0.5 h, 1 h, 2 h, and 4 h after a single dose (400 mL) of ju\u00e7ara juice, while urine was collected at baseline and 0-3 and 3-6 h after juice intake. Seven phenolic acids and conjugated phenolic acids were identified in urine deriving from the degradation of anthocyanins: protocatechuic acid, vanillic acid, vanillic acid glucuronide, hippuric acid, hydroxybenzoic acid, hydroxyphenylacetic acid, and ferulic acid derivative. In addition, kaempferol glucuronide was also found in urine as a metabolite of the parent compound in ju\u00e7ara juice. Ju\u00e7ara juice caused a decrease in the total oxidant status of serum after 0.5 h in comparison to baseline values ( < 0.05) and increased the phenolic acid metabolites excretion. This study shows the relationship between the production of metabolites of ju\u00e7ara juice and the total antioxidant status in human serum, indicating evidence of its antioxidant capacity."]