Association of variations with gestational diabetes mellitus risk in a Chinese population.

[{"label":"BACKGROUND","text":"The () plays a crucial role in insulin secretion. This study aimed to investigate the impact of gene polymorphisms on gestational diabetes mellitus (GDM)."},{"label":"METHODS","text":"The research objective was to select 500 patients with GDM and 502 control subjects. Rs13266634 and rs2466293 were genotyped using the SNPscan\u2122 genotyping assay. Statistical tests, such as the chi-square test, t-test, logistic regression, ANOVA, and meta-analysis, were conducted to determine the differences in genotypes, alleles, and their associations with GDM risk."},{"label":"RESULTS","text":"Statistically significant differences were observed in age, pregestational BMI, SBP, DBP, and parity between individuals with GDM and healthy subjects ( < 0.05). After adjusting for these factors, rs2466293 remained significantly associated with an increased risk of GDM in overall subjects (GG+AG vs. AA: OR = 1.310; 95% CI: 1.005-1.707; = 0.046, GG vs. AA: OR = 1.523; 95% CI: 1.010-2.298; = 0.045 and G vs. A: OR = 1.249; 95% CI: 1.029-1.516; = 0.024). Rs13266634 was still found to be significantly associated with a decreased risk of GDM in individuals aged \u2265 30 years (TT vs. CT+CC: OR = 0.615; 95% CI: 0.392-0.966; = 0.035, TT vs. CC: OR = 0.503; 95% CI: 0.294-0.861; = 0.012 and T vs. C: OR =0.723; 95% CI: 0.557-0.937; = 0.014). Additionally, the haplotype CG was found to be associated with a higher risk of GDM ( < 0.05). Furthermore, pregnant women with the CC or CT genotype of rs13266634 exhibited significantly higher mean blood glucose levels than those with the TT genotype ( < 0.05). Our findings were further validated by the results of a meta-analysis."},{"label":"CONCLUSION","text":"The rs2466293 polymorphism was found to be associated with an increased risk of GDM, while rs13266634 was associated with a decreased risk of GDM in individuals aged \u2265 30 years. These findings provide a theoretical basis for GDM testing."},{"copyright":"Copyright \u00a9 2023 Zeng, Tan, Han, Huang, Huang, Wei and Guo."}]